Design and structural investigations of Yb3+ substituted β-Ca3 (PO4 )2 contrast agents for bimodal NIR luminescence and X-ray CT imaging

Materials Science & Engineering. C, Materials for Biological Applications
Rugmani Meenambal, S Kannan

Abstract

The quest for the development of bone substitutes with contrast agents for diagnostic imaging subsists to distinguish synthetic bone from native human tissue. To this aim, ytterbium (Yb3+) substitutions in β-tricalcium phosphate (β-Ca3(PO4)2, β-TCP) as contrast agents has been developed to differentiate implant materials thereby, facilitating as host for bimodal imaging application by means of NIR luminescence and X-ray computed tomography techniques. A facile aqueous chemical precipitation route with the aid of surfactant is used for the synthesis of Yb3+ substitutions in β-Ca3(PO4)2. The characterization results affirms the ability of β-Ca3(PO4)2 to host 4.36 mol% of Yb3+ while the excess Yb3+ crystallizes as YbPO4. The structure refinement results favour the occupancy of Yb3+ at the Ca2+(5) site of β-Ca3(PO4)2. The absorption and photoluminescence spectra in the near infrared region with emission intensity ~1024 nm in the second biological window correspond to 2F5/2 → 2F7/2 transitions of Yb3+. The designed Yb3+ substituted β-Ca3(PO4)2 does not exhibit any toxicity in human osteosarcoma cell lines and delivers an excellent in vitro CT contrast ability allied by the enhanced signal intensity and high X-ray absorption coeffici...Continue Reading

Citations

Dec 7, 2019·Chemistry : a European Journal·Jacob C LutterVincent L Pecoraro
Oct 22, 2020·Dalton Transactions : an International Journal of Inorganic Chemistry·Xu-Sheng GaoXiao-Ming Ren
Sep 30, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·K R Sneha, G S Sailaja

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