Design and study of lamivudine oral controlled release tablets

AAPS PharmSciTech
Punna Rao RaviR N Saha

Abstract

The objective of this study was to design oral controlled release matrix tablets of lamivudine using hydroxypropyl methylcellulose (HPMC) as the retardant polymer and to study the effect of various formulation factors such as polymer proportion, polymer viscosity, and compression force on the in vitro release of drug. In vitro release studies were performed using US Pharmacopeia type 1 apparatus (basket method) in 900 mL of pH 6.8 phosphate buffer at 100 rpm. The release kinetics were analyzed using the zero-order model equation, Higuchi's square-root equation, and the Ritger-Peppas empirical equation. Compatibility of the drug with various excipients was studied. In vitro release studies revealed that the release rate decreased with increase in polymer proportion and viscosity grade. Increase in compression force was found to decrease the rate of drug release. Matrix tablets containing 60% HPMC 4000 cps were found to show good initial release (26% in first hour) and extended the release up to 16 hours. Matrix tablets containing 80% HPMC 4000 cps and 60% HPMC 15,000 cps showed a first-hour release of 22% but extended the release up to 20 hours. Mathematical analysis of the release kinetics indicated that the nature of drug rele...Continue Reading

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Citations

Jun 23, 2012·ACS Applied Materials & Interfaces·Steven J P McInnesNicolas H Voelcker
Sep 19, 2009·AAPS PharmSciTech·Kuldeep SinghMunish Ahuja
Apr 15, 2011·Journal of Pharmaceutical Sciences·S StrauchD M Barends
Jun 15, 2011·Journal of Controlled Release : Official Journal of the Controlled Release Society·Loraine L Y Chiu, Milica Radisic
May 28, 2013·International Journal of Biological Macromolecules·Akhilesh Vikram Singh, Lila Kanta Nath
Sep 30, 2020·Journal of Pharmacy Practice·William J HayesJoseph Berendse

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