Design and synthesis of 5-(5-nitrothiophen-2-yl)-3-phenyl-4,5-dihydro-1H-pyrazole derivatives with improved solubility and potential antituberculosis activity

Chemical Biology & Drug Design
Mihir KhambeteMukti Kanta Ray

Abstract

We report the design-synthesis of several nitrothiophene containing molecules as antituberculosis agents. The molecules were designed on the basis of previously reported nitrofuran molecules in our laboratory, and the α,β-unsaturated linker was modified to cyclized linker in order to overcome the challenge of low solubility and possible toxicity. The stereo-electronic properties such as HOMO, LUMO, and HOMO-LUMO gap along with other properties such as aqueous solvation energies and QPLogS values were studied. The designed molecules were synthesized and tested for in vitro antituberculosis activity, and some molecules were found to be highly active comparable to standard drugs. Further, the aqueous solubility was determined using visual inspection method and the designed molecules were found to be more soluble than their chalcone counterparts. Cytotoxicity studies were performed and the molecules were found to be non-cytotoxic. Electroanalytical studies proved nitro reduction as the mechanism of action for these molecules. Thus, this study provides potential nitrothiophene containing hits with improved solubility and reduced chances of toxicity.

References

Jul 18, 2002·Antimicrobial Agents and Chemotherapy·Juan-Carlos PalominoFrançoise Portaels
Oct 16, 2004·Journal of Medicinal Chemistry·Jeffrey J SutherlandDonald F Weaver
Jul 7, 2007·Natural Product Research·Mohamed Ashraf AliGanesan Suresh Pandian
Sep 21, 2010·Bioorganic & Medicinal Chemistry Letters·Nilesh R TawariMariam S Degani

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Citations

Aug 11, 2020·Drug Metabolism and Personalized Therapy·Mihir Pramod KhambeteMariam Sohel Degani
Mar 19, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Giovanni StelitanoLaurent Roberto Chiarelli
May 31, 2021·Trends in Microbiology·Mark LawsKhondaker Miraz Rahman

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