Design and synthesis of a solid-supported FR225659 derivative for its receptor screening

Organic Letters
Tatsuya ZenkohTakashi Takahashi

Abstract

[structure: see text] We describe the design and synthesis of latex particles attached to an FR225659 derivative to identify its receptor proteins. Two key building blocks were prepared by two-step degradation of FR225659 under basic conditions. The designed ligand showed an acceptable level of biological activity to make it of potential value for use in affinity-supported receptor identification. Affinity purification of FR225659-binding proteins using the latex nanoparticles provided three candidate receptor peptides for the biological activity.

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Citations

Jul 28, 2005·Natural Product Reports·Roberto G S Berlinck, Miriam H Kossuga
Sep 30, 2005·Natural Product Reports·Joseph P Michael
Feb 5, 2008·Biochemical and Biophysical Research Communications·Masafumi SuzukiHiroshi Handa
Sep 14, 2017·Medicinal Research Reviews·Xiao-Fei ShangKuo-Hsiung Lee
Feb 27, 2009·Chemical Record : an Official Publication of the Chemical Society of Japan ... [et Al.]·Satoshi SakamotoHiroshi Handa
Oct 12, 2005·Bioorganic & Medicinal Chemistry Letters·Makoto HasegawaHiroshi Handa

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