Design and Synthesis of Mannich bases as Benzimidazole Derivatives as Analgesic Agents

Anti-inflammatory & Anti-allergy Agents in Medicinal Chemistry
Prasanna A Datar, Saleel A Limaye

Abstract

Mannich bases were selected for 2D QSAR study to derive meaningful relationship between the structural features and analgesic activity. Using the knowledge of important features a novel series was designed to obtain improved analgesic activity. A series of novel Mannich bases 1-(N-substituted amino)methyl]-2-substituted benzimidazole derivatives were synthesized and were screened for analgesic activity. Some of these compounds showed promising analgesic activity when compared with the standard drug diclofenac sodium.

Citations

Aug 27, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Fatmah A S AlasmaryNazira Karodia

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