Design and synthesis of novel benzimidazole derivatives as inhibitors of hepatitis B virus

Bioorganic & Medicinal Chemistry
Yu LuoWei Lu

Abstract

A series of novel benzimidazole derivatives were synthesized and evaluated for their anti-hepatitis B virus (HBV) activity and cytotoxicity in the HepG2.2.15 cell line. The preliminary SAR was discussed. Compound 12a, with IC50<0.41 microM and SI>81.2, was the most promising compound and selected as the benchmark compound for further optimization.

Citations

Feb 20, 2014·European Journal of Medicinal Chemistry·Fan Zhang, Gang Wang
Oct 30, 2014·Chemical Biology & Drug Design·Rangappa S KeriBhari Mallanna Nagaraja
Dec 7, 2014·European Journal of Medicinal Chemistry·Geeta Yadav, Swastika Ganguly
Apr 30, 2015·Future Medicinal Chemistry·Haiyong JiaXinyong Liu
Sep 11, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Cheng-Ying HsiehMing-Hua Hsu
Aug 15, 2019·BMC Chemistry·Sumit TahlanBalasubramanian Narasimhan
Aug 14, 2021·Beilstein Journal of Organic Chemistry·Renato L CarvalhoEufrânio N da Silva Júnior

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