Design and Synthesis of Novel Hybrid Molecules against Malaria

International Journal of Medicinal Chemistry
Melanie Lödige, Luisa Hiersch

Abstract

The effective treatment of malaria can be very complex: Plasmodium parasites develop in multiple stages within a complex life cycle between mosquitoes as vectors and vertebrates as hosts. For the full and effective elimination of parasites, an effective drug should be active against the earliest stages of the Plasmodium infection: liver stages (reduce the progress of the infection), blood stages (cure the clinical symptoms), and gametocytes (inhibit the transmission cycle). Towards this goal, here we report the design, the synthetic methodology, and the characterization of novel hybrid agents with combined activity against Plasmodium liver stages and blood stages and gametocytes. The divergent synthetic approach allows the access to differently linked primaquine-chloroquine hybrid templates in up to eight steps.

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Citations

Dec 20, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Xhamla NqoroBlessing A Aderibigbe
Mar 16, 2017·Antimicrobial Agents and Chemotherapy·Drishti AgarwalSatish K Awasthi
Jul 5, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Anna MakowskaŁukasz Balewski
Jul 25, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Marina ZveaghintsevaFliur Z Macaev

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Methods Mentioned

BETA
one hybrid
six hybrid
two
NMR
column chromatography

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Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

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