Design and synthesis of novel isoxazole-based HDAC inhibitors

European Journal of Medicinal Chemistry
Paola ContiCarlo De Micheli

Abstract

A series of isoxazole-based histone deacetylase (HDAC) inhibitors structurally related to SAHA were designed and synthesized. The isoxazole moiety was inserted in the vicinity of the Zn(2+)-binding group in order to check its participation in the coordinating process.

Citations

Feb 16, 2016·Organometallics·Noelia CasanovaEnrique Oñate
Mar 13, 2012·European Journal of Medicinal Chemistry·Kentaro Kawai, Naoya Nagata
May 31, 2016·Bioorganic Chemistry·Mohammed ManalM J Nanjan
Apr 5, 2014·PLoS Computational Biology·Gerard J P van WestenJohn P Overington
Jul 14, 2018·Acta Crystallographica. Section E, Crystallographic Communications·Wissem ZemamoucheAbdelmadjid Debache
Jan 12, 2021·ChemMedChem·Jelena MelesinaWolfgang Sippl
May 18, 2021·European Journal of Medicinal Chemistry·Girish Chandra AryaVikas Jaitak

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