Design and use of silica-containing redox nanoparticles, siRNPs, for high-performance peritoneal dialysis

Biomaterials Science
Yukio NagasakiAki Hirayama

Abstract

The prevention of encapsulating peritoneal sclerosis (EPS) and the enhancement of dialysis efficiency are two important strategies that can improve the quality of life of patients undergoing peritoneal dialysis. We have thus far developed bionanoparticles that effectively scavenge reactive oxygen species (redox nanoparticles; RNPs). The objective of this study was to apply RNPs as a component of dialysate to reduce oxidative stress. Porous silica nanoparticles were combined with RNPs to enhance the effective adsorption capacity of low-molecular weight (LMW) compounds. The silica-containing RNPs (siRNPs) were confirmed to statistically decrease the level of creatinine and blood urea nitrogen in vivo. EPS model rats that underwent an intraperitoneal injection of chlorhexidine gluconate exhibited dysfunction of the peritoneal membrane. siRNP administration did not result in dysfunction of the peritoneal membrane. An LMW nitroxide compound, TEMPOL, also showed a weak peritoneal protective effect, although its efficiency was limited. No blood uptake of siRNPs was observed when they were administered into the peritoneal cavity. However, LMW-TEMPOL diffused into the blood stream, which might have decreased its effective concentration ...Continue Reading

References

Jun 17, 2005·Nephrology·Hideki Kawanishi
Oct 6, 2005·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Aileen GrassmannGail Brown
Dec 19, 2008·Journal of the American Society of Nephrology : JASN·Stephen P McDonaldKevan R Polkinghorne
Feb 5, 2009·Biomacromolecules·Toru YoshitomiYukio Nagasaki
Jun 23, 2009·Clinical Journal of the American Society of Nephrology : CJASN·Michaela C BrownUNKNOWN Scottish Renal Registry
Nov 26, 2009·Nature Reviews. Nephrology·Francesco LocatelliBenedetta Tucci
Apr 9, 2010·Kidney International·David W JohnsonKathryn J Wiggins
Feb 2, 2011·Nature Reviews. Nephrology·M Khaled Shamseddin, Patrick S Parfrey
Jul 28, 2011·Neurosurgery·Michael Salcman
Aug 21, 2013·Journal of Controlled Release : Official Journal of the Controlled Release Society·Toru YoshitomiYukio Nagasaki
Feb 15, 2014·World Journal of Clinical Cases·Federico GobbiZeno Bisoffi

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Citations

Jan 31, 2017·Journal of Biomaterials Science. Polymer Edition·Zhenyu GaoYukio Nagasaki
Jul 30, 2015·Biomaterials Science·Toru Yoshitomi, Yukio Nagasaki
Aug 3, 2016·Biomaterials Science·Zihang PengChangsheng Zhao
Nov 6, 2018·Journal of Nanobiotechnology·Izabela Sadowska-Bartosz, Grzegorz Bartosz
Feb 23, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Thu-Ha Thi NguyenYukio Nagasaki

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