Design and validation of diffusion MRI models of white matter

Frontiers of Physics
Ileana O Jelescu, Matthew D Budde

Abstract

Diffusion MRI is arguably the method of choice for characterizing white matter microstructure in vivo. Over the typical duration of diffusion encoding, the displacement of water molecules is conveniently on a length scale similar to that of the underlying cellular structures. Moreover, water molecules in white matter are largely compartmentalized which enables biologically-inspired compartmental diffusion models to characterize and quantify the true biological microstructure. A plethora of white matter models have been proposed. However, overparameterization and mathematical fitting complications encourage the introduction of simplifying assumptions that vary between different approaches. These choices impact the quantitative estimation of model parameters with potential detriments to their biological accuracy and promised specificity. First, we review biophysical white matter models in use and recapitulate their underlying assumptions and realms of applicability. Second, we present up-to-date efforts to validate parameters estimated from biophysical models. Simulations and dedicated phantoms are useful in assessing the performance of models when the ground truth is known. However, the biggest challenge remains the validation o...Continue Reading

References

May 1, 1992·Stroke; a Journal of Cerebral Circulation·H BenvenisteG A Johnson
May 1, 1990·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·M E MoseleyP R Weinstein
Jan 1, 1980·Acta histochemica·B de Campos VidalC Godo
May 1, 1995·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·A SzaferJ C Gore
Nov 1, 1994·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·C Beaulieu, P S Allen
Mar 1, 1994·Journal of Magnetic Resonance. Series B·P J BasserD LeBihan
Feb 15, 1994·Proceedings of the National Academy of Sciences of the United States of America·L L LatourC H Sotak
Dec 1, 1996·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·T NiendorfK Nicolay
Jan 1, 1997·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·G J StaniszR M Henkelman
Jan 29, 1998·The New England Journal of Medicine·B D TrappL Bö
Jul 11, 1998·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·T Q DuongJ J Neil
Apr 27, 2001·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·T Q DuongJ J Neil
May 4, 2002·Neuron·Dmitri B ChklovskiiCharles F Stevens
Nov 6, 2002·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Matthew D SilvaChristopher H Sotak
Nov 27, 2002·Proceedings of the National Academy of Sciences of the United States of America·Masaya TakahashiMichael E Selzer
Jan 24, 2003·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Mark D DoesJohn C Gore
Oct 3, 2003·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Dmitriy A YablonskiyJoseph J H Ackerman
Oct 3, 2003·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Kevin M BennettJames S Hyde
Oct 31, 2003·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·T E J BehrensS M Smith
Dec 9, 2003·Neuron·David S TuchVan J Wedeen
Oct 28, 2004·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Christopher D KroenkeDmitriy A Yablonskiy
Apr 22, 2005·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·James A GoodmanJeffrey J Neil
May 21, 2005·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Jens H JensenKyle Kaczynski
Aug 10, 2005·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Muriel PerrinDenis Lebihan
Sep 15, 2005·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Adam W Anderson
Dec 13, 2005·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Jacob EllegoodChristian Beaulieu
Aug 18, 2006·Current Opinion in Neurology·Heidi Johansen-Berg, Timothy E J Behrens
Dec 26, 2006·NeuroImage·Sune N JespersenDmitriy A Yablonskiy
Mar 16, 2007·IEEE Transactions on Bio-medical Engineering·Flavio Dell'AcquaFerruccio Fazio
Nov 21, 2007·Journal of Magnetic Resonance·Els FieremansIgnace Lemahieu
Dec 22, 2007·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·James A GoodmanJeffrey J Neil
Oct 17, 2008·Physiological Reviews·Eva Syková, Charles Nicholson
Nov 14, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ping Li, Timothy H Murphy
Mar 6, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Matthew D BuddeSheng-Kwei Song
Mar 11, 2009·IEEE Transactions on Medical Imaging·Matt G Hall, Daniel C Alexander
Jun 3, 2009·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Gregory T Balls, Lawrence R Frank
Jun 19, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·János A PergeVijay Balasubramanian
Jul 23, 2009·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Ofer PasternakYaniv Assaf

❮ Previous
Next ❯

Citations

Jun 19, 2019·Physics in Medicine and Biology·Noel M Naughton, John G Georgiadis
Oct 9, 2019·Topics in Magnetic Resonance Imaging : TMRI·András Jakab
Nov 26, 2019·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Sudhir RamannaJens H Jensen
Jul 24, 2020·NMR in Biomedicine·Michael J van RijsselJosien P W Pluim
Jul 21, 2020·Journal of Biophotonics·Daria K TuchinaValery V Tuchin
Mar 27, 2020·Neural Regeneration Research·Koji KamagataShigeki Aoki
Oct 16, 2019·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Noel M Naughton, John G Georgiadis
Dec 7, 2018·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Emilie T McKinnon, Jens H Jensen
Aug 28, 2020·Frontiers in Neurology·Germain ArribaratPatrice Péran
Oct 16, 2018·NMR in Biomedicine·Dmitry S NovikovValerij G Kiselev
Jun 4, 2019·Frontiers in Neurology·Luciana M MouraAdriana B Conforto
Dec 11, 2020·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Alexis ReymbautDaniel Topgaard
Jul 1, 2020·Physics in Medicine and Biology·Daniel J SullivanAssimina A Pelegri
Nov 2, 2020·Journal of Neuroscience Methods·Siawoosh Mohammadi, Martina F Callaghan
Jan 8, 2021·Acta Neuropathologica Communications·Xuan Vinh To, Fatima A Nasrallah
Jun 3, 2021·International Journal of Molecular Sciences·Koji KamagataShigeki Aoki
Jun 13, 2021·Human Brain Mapping·Irene VoldsbekkAnn-Marie G de Lange
Jun 18, 2021·Brain Communications·Sheelakumari RaghavanPrashanthi Vemuri
Jul 1, 2021·Journal of Magnetic Resonance Imaging : JMRI·Ilaria Boscolo GalazzoGloria Menegaz
Jun 23, 2021·Physics in Medicine and Biology·Joseph Yuan-Mou YangFernando Calamante
Jun 29, 2021·Journal of Neural Engineering·F CrucianiG Menegaz
Aug 20, 2021·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Paddy J SlatorJana Hutter
Sep 24, 2021·Medical Physics·Diego HernandoAli Pirasteh

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.