PMID: 8528130Aug 1, 1995Paper

Design considerations and performance of a prototype system for imaging neuronal depolarization in the brain using 'direct current' electrical resistance tomography

Physiological Measurement
K Boone, D S Holder

Abstract

The ability to image the impedance changes that accompany neuronal depolarization in the brain would constitute a major advance in neuroscience technology. Unfortunately, these changes are likely to be small and rapid and so difficult to measure. The impedance change at frequencies above 10 kHz, as used by conventional EIT systems, may be estimated to be about 0.1%. Modelling indicates that a much larger impedance change of about 7% may occur with DC or very-low-frequency excitation. Difficulties with this approach include a low permissive current level and high electrode impedance. We constructed a prototype system employing square wave excitation at 5 Hz to evaluate such problems. It was tested in a saline-filled tank, recording 4000 frames s-1 at a current level of 50 microA. After averaging 100 sets of frames, the signal to noise ratio was 40-50 dB, and reciprocity errors were mostly 10-20%. Images of discrete resistivity changes of less than 10% could be obtained, but with significant systematic errors. While our prototype would not be suitable for neurophysiological imaging as it stands, it has enabled us to determine the modifications that would be required to construct a system for this application.

References

Jan 1, 1992·Clinical Physics and Physiological Measurement : an Official Journal of the Hospital Physicists' Association, Deutsche Gesellschaft Für Medizinische Physik and the European Federation of Organisations for Medical Physics·A M SintonA D Leathard
Nov 1, 1991·Medical & Biological Engineering & Computing·D T GodinR N Scott
Aug 1, 1988·IEEE Transactions on Bio-medical Engineering·J RosellJ G Webster
Jan 1, 1988·Clinical Physics and Physiological Measurement : an Official Journal of the Hospital Physicists' Association, Deutsche Gesellschaft Für Medizinische Physik and the European Federation of Organisations for Medical Physics·H Griffiths
Jan 1, 1987·Clinical Physics and Physiological Measurement : an Official Journal of the Hospital Physicists' Association, Deutsche Gesellschaft Für Medizinische Physik and the European Federation of Organisations for Medical Physics·D C Barber, A D Seagar
Jan 1, 1987·Clinical Physics and Physiological Measurement : an Official Journal of the Hospital Physicists' Association, Deutsche Gesellschaft Für Medizinische Physik and the European Federation of Organisations for Medical Physics·B H Brown, A D Seagar
Jan 1, 1973·Journal of Neurobiology·C J HoffmanS Ochs
Jul 1, 1968·Journal of Neurophysiology·K A Klivington, R Galambos
Oct 1, 1968·Experimental Neurology·R Galambos, R Velluti
Nov 1, 1966·Medical & Biological Engineering·A H Flasterstein
Nov 1, 1966·Medical & Biological Engineering·A H Flasterstein
Jun 1, 1955·Journal of Cellular Physiology·W H FREYGANG, W M LANDAU
Feb 1, 1963·Experimental Neurology·J B RANCK
Feb 1, 1963·Experimental Neurology·J B RANCK
May 20, 1939·The Journal of General Physiology·K S Cole, H J Curtis

❮ Previous
Next ❯

Citations

Jun 1, 1995·Current Opinion in Neurobiology·K D Wickman, D E Clapham
Jun 5, 1998·Annual Review of Public Health·M L Durham
Jan 1, 1997·Annual Review of Psychology·C Palmer
Jan 16, 1998·Journal of Medical Engineering & Technology·K BooneB Brown

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Clinical Physics and Physiological Measurement : an Official Journal of the Hospital Physicists' Association, Deutsche Gesellschaft Für Medizinische Physik and the European Federation of Organisations for Medical Physics
D S Holder
Clinical Physics and Physiological Measurement : an Official Journal of the Hospital Physicists' Association, Deutsche Gesellschaft Für Medizinische Physik and the European Federation of Organisations for Medical Physics
D S Holder, A R Gardner-Medwin
© 2021 Meta ULC. All rights reserved