Design, construction, and characterization of a novel robotic welding fume generator and inhalation exposure system for laboratory animals

Journal of Occupational and Environmental Hygiene
James M AntoniniDavid G Frazer

Abstract

Respiratory effects observed in welders have included lung function changes, metal fume fever, bronchitis, and a possible increase in the incidence of lung cancer. Many questions remain unanswered regarding the causality and possible underlying mechanisms associated with the potential toxic effects of welding fume inhalation. The objective of the present study was to construct a completely automated, computer-controlled welding fume generation and inhalation exposure system to simulate real workplace exposures. The system comprised a programmable six-axis robotic welding arm, a water-cooled arc welding torch, and a wire feeder that supplied the wire to the torch at a programmed rate. For the initial studies, gas metal arc welding was performed using a stainless steel electrode. A flexible trunk was attached to the robotic arm of the welder and was used to collect and transport fume from the vicinity of the arc to the animal exposure chamber. Undiluted fume concentrations consistently ranged from 90-150 mg/m(3) in the animal chamber during welding. Temperature and humidity remained constant in the chamber during the welding operation. The welding particles were composed of (from highest to lowest concentration) iron, chromium, m...Continue Reading

References

Jan 1, 1979·The Annals of Occupational Hygiene·K J Al-ShammaR Hicks
May 1, 1991·The American Review of Respiratory Disease·S J Sferlazza, W S Beckett
Jan 1, 1985·American Journal of Industrial Medicine·C O WardP H Craig
May 1, 1982·Journal of Toxicology and Environmental Health·C M ParkerR W Voelker
Jan 1, 1981·The Annals of Occupational Hygiene·L R WhiteR J Richards
Oct 1, 1994·Environmental Health Perspectives·G OberdörsterB E Lehnert
Dec 2, 1999·Journal of Toxicology and Environmental Health. Part a·J M AntoniniJ D Brain
May 2, 2000·Toxicological Sciences : an Official Journal of the Society of Toxicology·K E DriscollR B Schlesinger
Aug 18, 2001·Toxicological Sciences : an Official Journal of the Society of Toxicology·I J YuH K Chung
Oct 29, 2002·Journal of Environmental Monitoring : JEM·Anthony T Zimmer
Feb 15, 2003·Critical Reviews in Toxicology·James M Antonini
Mar 20, 2003·American Journal of Industrial Medicine·James M AntoniniDavid A Whaley
Jul 2, 2003·Toxicological Sciences : an Official Journal of the Society of Toxicology·Michael D TaylorJames M Antonini
Dec 19, 2003·Journal of Toxicology and Environmental Health. Part a·James M AntoniniJenny R Roberts

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Citations

Mar 13, 2010·Archives of Toxicology·Krishnan SriramJames M Antonini
Sep 8, 2010·Journal of Toxicology and Environmental Health. Part a·Mario ScuriGiovanni Piedimonte
May 9, 2008·Journal of Occupational and Environmental Hygiene·Jean Dasch, James D'Arcy
Nov 2, 2012·Journal of Occupational and Environmental Hygiene·Jun WangOmar Es-Said
Jun 27, 2013·The Annals of Occupational Hygiene·James M AntoniniRobert R Mercer
Oct 11, 2013·Particle and Fibre Toxicology·Patti C Zeidler-ErdelyJames M Antonini
Jun 9, 2012·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Karol ZeleníkPavel Komínek
Jun 28, 2012·Journal of Immunotoxicology·Patti C Zeidler-ErdelyJames M Antonini
Oct 30, 2008·Journal of Immunotoxicology·James M Antonini, Jenny R Roberts
Aug 8, 2014·International Journal of Environmental Research and Public Health·Tao LiYuepu Pu
Aug 19, 2015·The Journal of Allergy and Clinical Immunology·Reetika SuriJonathan Grigg
Nov 22, 2015·International Archives of Occupational and Environmental Health·Marissa G BakerNoah S Seixas
Mar 24, 2015·Journal of Hazardous Materials·Jeong Hoon ByeonJeffrey T Roberts
Feb 14, 2008·Particle and Fibre Toxicology·Timothy R NurkiewiczVincent Castranova
Nov 5, 2010·Particle and Fibre Toxicology·Stephen S LeonardJames M Antonini
May 16, 2014·Journal of Occupational and Environmental Hygiene·L G CenaB T Chen
Aug 7, 2014·Aerosol Science and Technology : the Journal of the American Association for Aerosol Research·Jae Hong ParkThomas M Peters
Apr 5, 2017·Archives of Environmental & Occupational Health·Naglaa Abd El Khalik GobbaMohammed Abdalla Hussein
Apr 16, 2011·Journal of Environmental Monitoring : JEM·Michael KeaneBean Chen
Apr 2, 2019·Journal of Occupational and Environmental Hygiene·Patti C Zeidler-ErdelyJames M Antonini
Aug 28, 2010·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Krishnan SriramJames M Antonini
Oct 18, 2013·The Clinical Respiratory Journal·Engin TutkunAli Unlu
Feb 13, 2009·Journal of Environmental Monitoring : JEM·Michael KeaneJames Antonini
Dec 24, 2019·Toxicological Sciences : an Official Journal of the Society of Toxicology·James M AntoniniAaron Erdely
Jan 1, 2014·Aerosol Science and Technology : the Journal of the American Association for Aerosol Research·Lorenzo G CenaBean T Chen
Jan 6, 2017·Archives of Toxicology·Lauryn M FalconePatti C Zeidler-Erdely
Nov 19, 2020·Toxicology Reports·Ibrahim Lawal Abdullahi, Ali Sani

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Methods Mentioned

BETA
scanning
transmission electron microscopy
X-ray

Software Mentioned

MOUDI

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