Design, development, and first in vivo results of an implantable ventricular assist device, MicroVad

Artificial Organs
Wolfgang KerkhoffsHelmut Reul

Abstract

The design concept and first in vitro and in vivo results of a long-term implantable ventricular assist device system based on a microaxial blood pump are presented. The blood-immersed parts of the pump consist of a single-stage impeller and a proximally integrated microelectric motor. Both parts are surrounded by a pump housing currently made of polycarbonate to allow visible access to the blood-exposed parts. A titanium inflow cage attached to the tip of the housing is directly implanted into the left ventricular apex. The outflow of the pump is connected to the descending aorta by means of an e-PTFE graft. The overall dimensions of the device are 12 mm in outer diameter and about 50 mm in length. The calculated lifetime of the device is up to 2 years. The system underwent long-term durability tests, hydraulic performance tests, dynamic stability tests, and in vitro hemolysis and thrombogenicity tests. Furthermore, animal tests have been performed in adult Dorset sheep. In a first series, the pump has been placed extracorporeally; in a second series, the pump was completely implanted. Mean duration of the animal experiments of the second series was 31 days (range 8-110 days, n=14); no anticoagulation was administered over the...Continue Reading

References

Jan 17, 2002·The New England Journal of Medicine·E A RoseUNKNOWN Randomized Evaluation of Mechanical Assistance for the Treatment of Congestive Heart Failure (REMATCH) Study Group
Jan 13, 2006·Circulation·Thomas ThomUNKNOWN American Heart Association Statistics Committee and Stroke Statistics Subcommittee

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Citations

Feb 24, 2005·Artificial Organs·Paul S Malchesky
Oct 31, 2008·Artificial Organs·Michael TriepOliver Marseille
Jul 2, 2009·Artificial Organs·Diyar Saeed, Kiyotaka Fukamachi
Apr 25, 2007·Journal of Medical Engineering & Technology·K X QianJ B Zwischenberg
Jun 15, 2011·Medical Engineering & Physics·Daniel Timms
Aug 11, 2006·Cardiovascular Engineering·Kun-Xi Qian
Jul 2, 2020·The International Journal of Artificial Organs·A WisniewskiB Torner
Jan 11, 2007·The International Journal of Artificial Organs·M CikirikciogluB H Walpoth

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