Design of a calix[4]arene-functionalized metal-organic framework probe for highly sensitive and selective monitor of hippuric acid for indexing toluene exposure

Analytica Chimica Acta
Yaran DuQiong Jia

Abstract

In the present work, a novel metal-organic framework (MOF) fluorescent probe was prepared by post-synthetic modification of MIL-53-NH2(Al) with carboxylatocalix[4]arene (CC[4]A). The introduced CC[4]A could not only enhance the fluorescence performance and the recognition ability of the probe, but also sustain the high stability under UV light and moisture conditions. A method based on the as-synthesized CC[4]A@MIL-53-NH2(Al) probe was established for sensing hippuric acid. The detection limit was determined to be as low as 3.7 μg mL-1. Over the concentration range of 0.005-3 mg mL-1, the calibration curve was obtained with a satisfactory linearity (R2 = 0.993). The method was successfully used for rapid and highly selective direct monitor of hippuric acid in human urine. The sensor had great potential to be used as a simple diagnostic tool for hippuric acid in human urine which is regarded as a biological index of toluene exposure.

Citations

Nov 3, 2020·Chemical Society Reviews·Ricardo F MendesFilipe A Almeida Paz
Mar 19, 2021·Methods and Applications in Fluorescence·Xuelin MaShengli Yong
Jan 15, 2019·Journal of Agricultural and Food Chemistry·Chunhua LiZhonghong Li
Nov 18, 2021·Dalton Transactions : an International Journal of Inorganic Chemistry·Soumya MukherjeeSujit K Ghosh

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