Design of a Clinical Decision Support System for Fracture Prediction Using Imbalanced Dataset

Journal of Healthcare Engineering
Yung-Fu ChenHsuan-Hung Lin

Abstract

More than 1 billion people suffer from chronic respiratory diseases worldwide, accounting for more than 4 million deaths annually. Inhaled corticosteroid is a popular medication for treating chronic respiratory diseases. Its side effects include decreased bone mineral density and osteoporosis. The aims of this study are to investigate the association of inhaled corticosteroids and fracture and to design a clinical support system for fracture prediction. The data of patients aged 20 years and older, who had visited healthcare centers and been prescribed with inhaled corticosteroids within 2002-2010, were retrieved from the National Health Insurance Research Database (NHIRD). After excluding patients diagnosed with hip fracture or vertebrate fractures before using inhaled corticosteroid, a total of 11645 patients receiving inhaled corticosteroid therapy were included for this study. Among them, 1134 (9.7%) were diagnosed with hip fracture or vertebrate fracture. The statistical results showed that demographic information, chronic respiratory diseases and comorbidities, and corticosteroid-related variables (cumulative dose, mean exposed daily dose, follow-up duration, and exposed duration) were significantly different between frac...Continue Reading

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Citations

Mar 23, 2021·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Julien SmetsDidier Hans
Oct 23, 2021·Endocrinology and Metabolism·Sung Hye Kong, Chan Soo Shin

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Software Mentioned

SMOTE
EasyEnsemble
SPSS
BalancedCascade
Cluster

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