PMID: 9555778Apr 29, 1998Paper

Design of a clinical trial for the assessment of cardioversion using transesophageal echocardiography (The ACUTE Multicenter Study). Steering and Publications Committees of the ACUTE Study

The American Journal of Cardiology

Abstract

Patients with atrial fibrillation (AF) undergoing cardioversion are at an increased risk of cardioembolic stroke and require anticoagulation. The Assessment of Cardioversion Using Transesophageal Echocardiography (ACUTE) Multicenter Study is a randomized clinical trial of patients undergoing electrical cardioversion of AF of >2 days' duration comparing a transesophageal-guided strategy (TEE) with brief anticoagulation to the conventional anticoagulation strategy. Patients randomly assigned to the TEE-guided strategy receive therapeutic anticoagulation before TEE and cardioversion, followed by 4 weeks of anticoagulation. Patients with thrombus imaged by TEE have postponement of cardioversion, continue anticoagulation for 3 weeks, and undergo a repeat TEE. Conventional strategy patients receive 3 weeks of anticoagulation before cardioversion, followed by 4 weeks of anticoagulation after cardioversion. The primary end point events are ischemic stroke, transient ischemic attack, and systemic embolization for an 8-week period from enrollment. Secondary end points are major and minor bleeding, all-cause mortality, successful return to and maintenance of sinus rhythm, and cost effectiveness. Analysis is based on the intention-to-treat...Continue Reading

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Citations

Sep 15, 2001·The New England Journal of Medicine·P J Devereaux, S Yusuf
May 11, 2001·The New England Journal of Medicine·A L KleinUNKNOWN Assessment of Cardioversion Using Transesophageal Echocardiography Investigators
Jun 2, 2000·Pacing and Clinical Electrophysiology : PACE·J CarlssonY D Rosenberg
Jul 1, 1999·Clinics in Chest Medicine·G S Francis
Jan 31, 2006·American Heart Journal·Allan L KleinUNKNOWN ACUTE Steering and Publications Committee for the ACUTE Investigators
Nov 6, 2001·Journal of the American College of Cardiology·A L KleinR A Grimm
Nov 23, 2006·Journal of the American College of Cardiology·Oussama M WazniAllan L Klein
Mar 10, 2001·Cardiology Clinics·M Thamilarasan, A L Klein
Dec 22, 2000·Current Opinion in Cardiology·T P Donahue, J B Conti
Jan 27, 2017·International Journal of Technology Assessment in Health Care·David HaileyElena Villamil
Sep 5, 2013·Environmental Management·Anthony P Clevenger, Angela V Kociolek
Mar 26, 2014·The Cochrane Database of Systematic Reviews·Marlies ZwerinkTanja Effing
Nov 2, 2007·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Glenn R Buttermann, William J Mullin

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