Abstract
Patients with atrial fibrillation (AF) undergoing cardioversion are at an increased risk of cardioembolic stroke and require anticoagulation. The Assessment of Cardioversion Using Transesophageal Echocardiography (ACUTE) Multicenter Study is a randomized clinical trial of patients undergoing electrical cardioversion of AF of >2 days' duration comparing a transesophageal-guided strategy (TEE) with brief anticoagulation to the conventional anticoagulation strategy. Patients randomly assigned to the TEE-guided strategy receive therapeutic anticoagulation before TEE and cardioversion, followed by 4 weeks of anticoagulation. Patients with thrombus imaged by TEE have postponement of cardioversion, continue anticoagulation for 3 weeks, and undergo a repeat TEE. Conventional strategy patients receive 3 weeks of anticoagulation before cardioversion, followed by 4 weeks of anticoagulation after cardioversion. The primary end point events are ischemic stroke, transient ischemic attack, and systemic embolization for an 8-week period from enrollment. Secondary end points are major and minor bleeding, all-cause mortality, successful return to and maintenance of sinus rhythm, and cost effectiveness. Analysis is based on the intention-to-treat...Continue Reading
References
Oct 1, 1992·Chest·A LaupacisW Feinberg
Jan 1, 1992·Annals of Internal Medicine
Mar 1, 1991·Circulation·W G DanielK Dennig
Jul 15, 1989·The American Journal of Cardiology·R C BansalK R Jutzy
Nov 1, 1989·Journal of the American College of Cardiology·H K ChopraA Pacifico
Mar 1, 1989·Journal of the American College of Cardiology·W J ManningP C Come
Jun 1, 1988·Journal of the American College of Cardiology·W G DanielP R Lichtlen
Nov 1, 1986·American Heart Journal·D RoyR Cartier
Oct 1, 1985·Journal of the American College of Cardiology·S BeppuS Izumi
Jul 1, 1969·British Heart Journal·C McCarthyD W Barritt
Feb 1, 1981·British Heart Journal·P SchweizerS Effert
Oct 1, 1995·Chest·A LaupacisA Jacobson
May 1, 1995·Journal of the American College of Cardiology·W J ManningP S Douglas
Jun 1, 1995·American Heart Journal·M F StoddardR A Longaker
Dec 1, 1994·Circulation·W J ManningP S Douglas
Nov 1, 1993·Journal of the American College of Cardiology·R A GrimmA L Klein
Feb 1, 1994·Circulation·S M VaziriD Levy
Feb 1, 1996·The American Journal of Cardiology·D FatkinM Feneley
Mar 15, 1996·Circulation·E N PrystowskyD G Wyse
Jul 1, 1996·Progress in Cardiovascular Diseases·D Y LeungA L Klein
Feb 1, 1997·Annals of Internal Medicine·A L KleinK L Arheart
Feb 1, 1997·Annals of Internal Medicine·E N Prystowsky
Mar 15, 1997·Journal of the American College of Cardiology·M D CheitlinT J Ryan
Mar 18, 1997·Circulation·M D CheitlinL D Gillam
Jul 1, 1997·Journal of Cardiovascular Electrophysiology·R D Riley, E L Pritchett
Citations
Jan 29, 2002·European Journal of Heart Failure·Amala A LouisJohn G F Cleland
Jan 14, 2003·Pharmacotherapy·Anna M Wodlinger, John A Pieper
Sep 15, 2001·The New England Journal of Medicine·P J Devereaux, S Yusuf
May 11, 2001·The New England Journal of Medicine·A L KleinUNKNOWN Assessment of Cardioversion Using Transesophageal Echocardiography Investigators
Jun 2, 2000·Pacing and Clinical Electrophysiology : PACE·J CarlssonY D Rosenberg
Apr 17, 2012·The American Journal of Cardiology·Hirad YarmohammadiAllan L Klein
Apr 23, 2005·American Heart Journal·Susan E JasperUNKNOWN ACUTE Investigators
Aug 24, 2000·The American Journal of Cardiology·R D MurrayA L Klein
Jul 1, 1999·Clinics in Chest Medicine·G S Francis
Jan 31, 2006·American Heart Journal·Allan L KleinUNKNOWN ACUTE Steering and Publications Committee for the ACUTE Investigators
Nov 6, 2001·Journal of the American College of Cardiology·A L KleinR A Grimm
Nov 23, 2006·Journal of the American College of Cardiology·Oussama M WazniAllan L Klein
Apr 6, 2004·Journal of the American College of Cardiology·Allan L KleinUNKNOWN ACUTE Investigators
Jul 16, 2003·The American Journal of Cardiology·Allan L KleinUNKNOWN ACUTE Investigators
Mar 10, 2001·Cardiology Clinics·M Thamilarasan, A L Klein
Dec 22, 2000·Current Opinion in Cardiology·T P Donahue, J B Conti
Jan 27, 2017·International Journal of Technology Assessment in Health Care·David HaileyElena Villamil
Sep 5, 2013·Environmental Management·Anthony P Clevenger, Angela V Kociolek
Mar 26, 2014·The Cochrane Database of Systematic Reviews·Marlies ZwerinkTanja Effing
Jan 5, 2011·Circulation·Rangadham NagarakantiStuart J Connolly
Nov 2, 2007·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Glenn R Buttermann, William J Mullin