Design of a Controlled Trial of Cascade Screening for Hypercholesterolemia: The (CASH) Study

Journal of Personalized Medicine
Iftikhar J Kullo, Kent R Bailey

Abstract

To inform guidelines for screening family members of patients with familial hypercholesterolemia (FH), we designed a clinical trial to compare the yield of cascade screening in FH patients with and without an identifiable pathogenic variant. Participants with hypercholesterolemia (Low-density lipoprotein cholesterol (LDL-C) > 155 mg/dL) underwent sequencing of LDLR, APOB, and PCSK9 and genotyping of six single nucleotide polymorphisms associated with LDL-C followed by calculation of a polygenic score for LDL-C. We identified 24 patients with definite FH (pathogenic variant in one of the three FH genes), 76 patients with probable FH (Dutch lipid clinic network (DLCN) score ≥ 6, no pathogenic variant), and 262 patients with possible FH (DLCN score 3⁻5, no pathogenic variant). We will enroll 50 patients with definite FH by recruiting an additional 26 from the FH Clinic at Mayo and 50 patients each with probable and possible FH, matching on age and sex. Family members of patients with definite FH will undergo testing for the relevant pathogenic variant using saliva kits and family members of those with probable/possible FH will have a lipid profile checked. We will assess the number of new cases detected (defined as presence of a p...Continue Reading

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Citations

Oct 23, 2019·Circulation. Genomic and Precision Medicine·Christopher LeeIftikhar J Kullo
Feb 6, 2019·Journal of Personalized Medicine·Rachele M Hendricks-Sturrup, Christine Y Lu
Apr 16, 2021·NPJ Genomic Medicine·Seyedmohammad SaadatagahIftikhar J Kullo

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Methods Mentioned

BETA
genotyping

Clinical Trials Mentioned

NCT03640234

Software Mentioned

REDCap ( Research Electronic Data Capture )
SAS

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