Design of a Dual-Technology Fusion Sensor Chip with a Ring Electrode for Biosensing Application

Micromachines
Cheng MaWei Zheng

Abstract

Quartz crystal microbalance (QCM) is still a new high-precision surface detection technique. However, the adsorption quality detected by the QCM currently contains a solvent-coupling quality and cannot separate the actual biomolecular mass. Local surface plasmon resonance (LSPR) can detect the mass of biomolecules, but requires a certain contrast between the solvent of the surrounding medium and the refractive index of the adsorbed layer. The sensor chip, combining two compatible technologies, can realize the simultaneous detection of biomolecules and improve the refractive index sensitivity. The structure of our chip is to prepare the ring-shaped gold electrode on the upper surface of the quartz crystal, the circular gold electrode on the bottom surface, and the spherical gold nanoparticles arrays in the center region of the ring electrode to form a QCM/LSPR dual-technology chip. Through simulation, we finally get the size of the best energy trap by the two electrodes on the upper surface and the lower surface: the ring-top electrode with a thickness of 100 nm, an inner diameter of 4 mm, and an outer diameter of 8 mm; and the bottom electrode with a thickness of 100 nm and a radius of 6 mm. By comparing the refractive index se...Continue Reading

References

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Methods Mentioned

BETA
quartz crystal microbalance
QCM-D
surface plasmon resonance
chip
quartz crystal
chips
quartz crystal chip

Software Mentioned

ANSYS

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