journal cover

Design of a MCoTI-Based Cyclotide with Angiotensin (1-7)-Like Activity

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry

Jan 29, 2016

Teshome L AboyeJulio A Camarero

Abstract

We report for the first time the design and synthesis of a novel cyclotide able to activate the unique receptor of angiotensin (1-7) (AT1-7), the MAS1 receptor. This was accomplished by grafting an AT1-7 peptide analog onto loop 6 of cyclotide MCoTI-I using isopeptide bonds to preserve ...read more

Mentioned in this Paper

Cricetulus
Muscle Rigidity
Angiotensin I (1-7)
Carboxy-Terminal Amino Acid
Thioester
G-Protein-Coupled Receptors
Renin-Angiotensin Pathway
Cyclotides
Protoplasm
Antagonist Muscle Action
2
22
Paper Details
References
  • References32
  • Citations8
1234
  • References32
  • Citations8
1

Similar Papers Found In These Feeds

GPCRs Signaling Pathway

G-protein coupled receptors (GPCRs) are membrane receptors implicated in the pathophysiology of various diseases, including neurodegenerative disorders, infectious diseases, and cancer. Here is the latest research on GPCR signaling pathway.

G-Protein-Coupled Receptors

G-protein-coupled receptors (GPCRs), the largest family of integral membrane proteins, participate in the regulation of many physiological functions and are the targets of approximately 30% of currently marketed drugs. Here is the latest research.

Corticobasal Degeneration

Corticobasal Degeneration (CBD)is a rare, neurodegenerative disease of the cerebral cortex and the basal ganglia, characterized by movement disorders. Discover the latest research on CBD here.

Intestinal Parasites & Cancer

Parasitic diseases may affect several hallmarks of cancer. Understanding how these parasites promote oncogenesis will aid in the development of novel treatments for infection-associated malignancy. Discover the latest research on parasites and cancer here.

Sulfonamides

Sulfonamide is a functional group found as the base of several classes of drugs. Sulfonamides can act as synthetic antimicrobial agents, anti-diabetics, diuretics, anticonvulsants, etc. Here is the latest research.

Related Papers

Journal of Medicinal Chemistry

Design of a novel cyclotide-based CXCR4 antagonist with anti-human immunodeficiency virus (HIV)-1 activity

Journal of Medicinal ChemistryNovember 16, 2012
Teshome L AboyeJulio A Camarero
Angewandte Chemie

Backbone dynamics of cyclotide MCoTI-I free and complexed with trypsin

Angewandte ChemieAugust 18, 2010
Shadakshara S PuttamadappaJulio A Camarero
© 2020 Meta ULC. All rights reserved

Design of a MCoTI-Based Cyclotide with Angiotensin (1-7)-Like Activity

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry

Jan 29, 2016

Teshome L AboyeJulio A Camarero

PMID: 26821010

DOI: 10.3390/molecules21020152

Abstract

We report for the first time the design and synthesis of a novel cyclotide able to activate the unique receptor of angiotensin (1-7) (AT1-7), the MAS1 receptor. This was accomplished by grafting an AT1-7 peptide analog onto loop 6 of cyclotide MCoTI-I using isopeptide bonds to preserve ...read more

Mentioned in this Paper

Cricetulus
Muscle Rigidity
Angiotensin I (1-7)
Carboxy-Terminal Amino Acid
Thioester
G-Protein-Coupled Receptors
Renin-Angiotensin Pathway
Cyclotides
Protoplasm
Antagonist Muscle Action
2
22

Similar Papers Found In These Feeds

GPCRs Signaling Pathway

G-protein coupled receptors (GPCRs) are membrane receptors implicated in the pathophysiology of various diseases, including neurodegenerative disorders, infectious diseases, and cancer. Here is the latest research on GPCR signaling pathway.

G-Protein-Coupled Receptors

G-protein-coupled receptors (GPCRs), the largest family of integral membrane proteins, participate in the regulation of many physiological functions and are the targets of approximately 30% of currently marketed drugs. Here is the latest research.

Related Papers

Journal of Medicinal Chemistry

Design of a novel cyclotide-based CXCR4 antagonist with anti-human immunodeficiency virus (HIV)-1 activity

Journal of Medicinal ChemistryNovember 16, 2012
Teshome L AboyeJulio A Camarero
Angewandte Chemie

Backbone dynamics of cyclotide MCoTI-I free and complexed with trypsin

Angewandte ChemieAugust 18, 2010
Shadakshara S PuttamadappaJulio A Camarero
Paper Details
References
  • References32
  • Citations8
1234
  • References32
  • Citations8
1
/papers/design-of-a-mcoti-based-cyclotide-with/26821010