Design of a modulated orthovoltage stereotactic radiosurgery system

Medical Physics
Jessica M FagerstromWesley S Culberson

Abstract

To achieve stereotactic radiosurgery (SRS) dose distributions with sharp gradients using orthovoltage energy fluence modulation with inverse planning optimization techniques. A pencil beam model was used to calculate dose distributions from an orthovoltage unit at 250 kVp. Kernels for the model were derived using Monte Carlo methods. A Genetic Algorithm search heuristic was used to optimize the spatial distribution of added tungsten filtration to achieve dose distributions with sharp dose gradients. Optimizations were performed for depths of 2.5, 5.0, and 7.5 cm, with cone sizes of 5, 6, 8, and 10 mm. In addition to the beam profiles, 4π isocentric irradiation geometries were modeled to examine dose at 0.07 mm depth, a representative skin depth, for the low energy beams. Profiles from 4π irradiations of a constant target volume, assuming maximally conformal coverage, were compared. Finally, dose deposition in bone compared to tissue in this energy range was examined. Based on the results of the optimization, circularly symmetric tungsten filters were designed to modulate the orthovoltage beam across the apertures of SRS cone collimators. For each depth and cone size combination examined, the beam flatness and 80-20% and 90-10% ...Continue Reading

References

Mar 1, 1992·Medical Physics·A AhnesjöA Trepp
Aug 1, 1991·International Journal of Radiation Oncology, Biology, Physics·L A NedziJ S Loeffler
Feb 1, 1995·Medical Physics·M S HuqN Suntharalingam
May 1, 1995·Medical Physics·D W RogersT R Mackie
Jan 1, 1994·Journal of Vascular and Interventional Radiology : JVIR·L K WagnerR A Geise
Jul 4, 1998·International Journal of Radiation Oncology, Biology, Physics·S C YoonK S Shinn
Mar 11, 1999·Physics in Medicine and Biology·J H Hubbell
Dec 10, 1999·Medical Physics·G M MoraD W Rogers
Nov 6, 2004·Journal of Neuro-oncology·Edward R LawsRod Oskouian
May 21, 2005·Minimally Invasive Neurosurgery : MIN·K KajiwaraM Suzuki
May 28, 2005·Neurosurgery·Steven D ChangJohn R Adler
Feb 7, 2006·International Journal of Radiation Oncology, Biology, Physics·Nicolas MassagerMarc Levivier
May 6, 2006·Physics in Medicine and Biology·Lauren O'MalleyMichael Sharpe
Oct 24, 2007·Physics in Medicine and Biology·Michael W KissickPeter W Hoban
Oct 30, 2008·Journal of Experimental & Clinical Cancer Research : CR·Luis-Alberto MedinaMaría-Ester Brandan
Mar 27, 2009·Stereotactic and Functional Neurosurgery·Nicolas MassagerMarc Levivier
May 30, 2009·Physics in Medicine and Biology·Manuel RodriguezEdward Graves
Mar 20, 2010·Australasian Physical & Engineering Sciences in Medicine·F Q ChenP Metcalfe
Dec 17, 2010·Medical Physics·B R Muir, D W O Rogers
May 28, 2011·Physics in Medicine and Biology·Frank VerhaegenErik Tryggestad
Jan 3, 2012·International Journal of Radiation Oncology, Biology, Physics·Ehsan H BalagamwalaSamuel T Chao
Mar 14, 2012·Physics in Medicine and Biology·K Zink, J Wulff
May 16, 2012·Journal of Applied Clinical Medical Physics·Stephen F KryMarilyn Stovall
Mar 4, 2014·Physics in Medicine and Biology·Robin HillClive Baldock
Feb 20, 2015·Journal of Radiation Research·Rezvan AzimiSusanta K Hui
May 13, 2015·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·M JermoumiW Ngwa

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