PMID: 32133105DOI: 10.1039/c9md00254eMar 7, 2020Paper
Design of a MUC1-based tricomponent vaccine adjuvanted with FSL-1 for cancer immunotherapy
MedChemComm
Mingjing LiWei Zhao
Abstract
MUC1 is an attractive target for cancer vaccines as a result of its over-expression and aberrant glycosylation pattern on many tumor cells. However, the low immunogenicity of MUC1 and immune tolerance have limited its application. Herein, we designed MUC1-based tricomponent antitumor vaccines adjuvanted with fibroblast stimulating lipopeptide 1 (FSL-1). Immunological results indicate that the glycosylated tricomponent vaccine candidate has elicited both humoral and cellular immune responses. The induced antibodies could effectively bind to MCF-7. Furthermore, the vaccine exhibited an obvious reduction in tumour burden.
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Citations
Aug 4, 2020·Journal of Cellular and Molecular Medicine·Shunda WangYupei Zhao
Oct 21, 2020·Chemical Communications : Chem Comm·Han LinZhimeng Wu
Mar 12, 2021·Glycoconjugate Journal·Inka Brockhausen, Jacob Melamed
Aug 3, 2021·Chemical Reviews·Lu SuGuosong Chen
Oct 4, 2019·Bioconjugate Chemistry·Mikkel H S MarqvorsenSander I van Kasteren
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Methods Mentioned
BETA
glycosylation
ELISA
flow cytometry
FACS
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