Design of a MUC1-based tricomponent vaccine adjuvanted with FSL-1 for cancer immunotherapy

MedChemComm
Mingjing LiWei Zhao

Abstract

MUC1 is an attractive target for cancer vaccines as a result of its over-expression and aberrant glycosylation pattern on many tumor cells. However, the low immunogenicity of MUC1 and immune tolerance have limited its application. Herein, we designed MUC1-based tricomponent antitumor vaccines adjuvanted with fibroblast stimulating lipopeptide 1 (FSL-1). Immunological results indicate that the glycosylated tricomponent vaccine candidate has elicited both humoral and cellular immune responses. The induced antibodies could effectively bind to MCF-7. Furthermore, the vaccine exhibited an obvious reduction in tumour burden.

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Citations

Aug 4, 2020·Journal of Cellular and Molecular Medicine·Shunda WangYupei Zhao
Mar 12, 2021·Glycoconjugate Journal·Inka Brockhausen, Jacob Melamed
Aug 3, 2021·Chemical Reviews·Lu SuGuosong Chen

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Methods Mentioned

BETA
glycosylation
ELISA
flow cytometry
FACS

Related Concepts

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Cancer Vaccines

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