Design of a Multicompartment Hydrogel that Facilitates Time-Resolved Delivery of Combination Therapy and Synergized Killing of Glioblastoma

Angewandte Chemie
Poulami MajumderJoel P Schneider

Abstract

There is significant current interest in identifying new combination therapies that synergize to treat disease, and it is becoming increasingly clear that the temporal resolution of their administration greatly impacts efficacy. To facilitate effective delivery, a multicompartment hydrogel material was developed that is composed of spherical vesicles interlaced within a self-assembled peptide-based network of physically crosslinked fibrils that allows time-resolved independent co-delivery of small molecules. This material architecture effectively delivers the EGFR kinase inhibitor Erlotinib (ERL) and Doxorubicin (DOX, DNA intercalator) in an ERL→DOX sequential manner to synergistically kill glioblastoma, the most aggressive form of brain cancer.

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Citations

Sep 17, 2020·Advanced Healthcare Materials·Ying CaiPengcheng Zhang
Sep 12, 2019·Biomaterials Science·Qian WangJianfeng Liu
Nov 25, 2020·Journal of Biomaterials Science. Polymer Edition·Luisa L PalmeseKristi L Kiick
Dec 5, 2020·Advanced Healthcare Materials·Fatemeh PoustchiMohammad-Ali Shahbazi
Dec 29, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yiwen Zhang, Chen Jiang
Jan 21, 2021·Frontiers in Bioengineering and Biotechnology·Galit Fichman, Joel P Schneider
Aug 20, 2020·Chemical Reviews·Hongjian HeBing Xu
Apr 28, 2020·ACS Omega·Chaitanya Kumar ThotaBeate Koksch
Dec 12, 2020·ACS Biomaterials Science & Engineering·David G LeachJeffrey D Hartgerink

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