Design of a PROspective multi-national CLOTBUST collaboration on reperfusion therapies for stroke (CLOTBUST-PRO)

International Journal of Stroke : Official Journal of the International Stroke Society
Maher SaqqurCLOTBUST-PRO Investigators

Abstract

The benefit of intravenous (i.v.) tissue plasminogen activator (tPA) in acute ischemic stroke (IS) is attributable to lysis of thrombus and restoration of perfusion to ischemic but not yet infarcted brain. Our multicentre collaborative group prospectively implemented a protocol for transcranial Doppler assessment of intracranial recanalization with tPA treatment based on the CLOTBUST clinical trial (CLOTBUST-PRO). We aim to determine whether early recanalization (within 1 h from tPA bolus) is independently associated with better 3-month outcome in patients with intracranial arterial occlusions and correlates to a shorter time interval elapsed from symptom onset to tPA bolus. Consecutive patients with acute IS due to intracranial arterial occlusions will be treated with standard i.v.-tPA and continuously monitored with 2 MHz Transcranial Doppler for arterial recanalization. Early recanalization will be determined with the previously validated Thrombolysis in Brain Ischemia flow-grading system within 60 min after tPA bolus. Power calculations are based on the assumption of alpha=0.05 (two-sided test) and probabilities of functional independence at 3 months of 0.50 and 0.35 in patients with early complete recanalization and persis...Continue Reading

References

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Mar 3, 2007·Stroke; a Journal of Cerebral Circulation·Georgios TsivgoulisAndrei V Alexandrov

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Citations

Nov 29, 2012·Journal of Neurosciences in Rural Practice·Lokesh Bathala
Aug 28, 2010·Stroke Research and Treatment·Vijay K SharmaBernard P L Chan
Feb 11, 2011·Expert Review of Neurotherapeutics·Alexandre Amaral-SilvaCarlos A Molina
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Apr 1, 2011·Expert Opinion on Drug Discovery·Monika KillerErasmia Broussalis
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Nov 29, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Thanasekaran JayakumarJoen-Rong Sheu
Aug 28, 2012·Experimental Neurology·Mohamad El AmkiIsabelle Margaill
Nov 19, 2014·Frontiers in Neurology·Georgios TsivgoulisAndrei V Alexandrov
Jul 12, 2014·Chinese Journal of Integrative Medicine·Thanasekaran JayakumarJoen-rong Sheu
Jun 28, 2013·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Milija D MijajlovicNadezda Covickovic-Sternic
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Jan 29, 2010·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Marta Rubiera, Andrei V Alexandrov
May 3, 2014·The Cochrane Database of Systematic Reviews·Kate E LagerAndrew D Wilson
Feb 7, 2020·Journal of Stroke·Georgios TsivgoulisUNKNOWN CLOTBUST-PRO investigators
Dec 10, 2008·Stroke; a Journal of Cerebral Circulation·Andrei V Alexandrov

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Methods Mentioned

BETA
PCA

Software Mentioned

CLOTBUST
PRO

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