Design of a self-cleaning thermoresponsive nanocomposite hydrogel membrane for implantable biosensors

Acta Biomaterialia
Rebecca M GantGerard L Coté

Abstract

Following implantation of a biosensor, adhesion of proteins and cells and eventual fibrous encapsulation will limit analyte diffusion and impair sensor performance. A thermoresponsive nanocomposite hydrogel was developed as a self-cleaning biosensor membrane to minimize the effect of the host response and its utility for an optical glucose sensor, demonstrated here. It was previously reported that thermoresponsive nanocomposite hydrogels prepared from photopolymerization of an aqueous solution of N-isopropylacrylamide (NIPAAm) and polysiloxane colloidal nanoparticles released adhered cells with thermal cycling. However, poly(N-isopropylacrylamide) hydrogels exhibit a volume phase transition temperature (VPTT) of approximately 33-34 degrees C, which is below body temperature. Thus, the hydrogel would be in a collapsed state in vivo, which would ultimately limit diffusion of the target analyte (e.g., glucose) to the encapsulated sensor. In this study, the VPTT of the nanocomposite hydrogel was increased by introducing N-vinylpyrrolidone (NVP) as a comonomer, so that the hydrogel was in the swollen state in vivo. This thermoresponsive nanocomposite hydrogel was prepared by the photopolymerization of an aqueous solution of NIPAAm, ...Continue Reading

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Citations

Jan 10, 2016·International Journal of Pharmaceutics·Aparna Sai Laxmi RangabhatlaOnpreeya Boonrat
Jan 3, 2012·Colloids and Surfaces. B, Biointerfaces·Yuanyuan AnZushun Xu
Mar 17, 2016·Heart Failure Reviews·Rita Maalouf, Steven Bailey
Dec 7, 2013·ACS Applied Materials & Interfaces·Alexander A AbrahamMelissa A Grunlan
Sep 13, 2017·Macromolecular Rapid Communications·A Kristen MeansMelissa A Grunlan
Jan 8, 2013·Soft Matter·Ruochong FeiMelissa Ann Grunlan
Dec 13, 2012·Advanced Healthcare Materials·A Nolan Wilson, Anthony Guiseppi-Elie
Jun 24, 2014·Macromolecular Bioscience·Ruochong FeiMelissa A Grunlan
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Jan 30, 2018·International Journal of Pharmaceutics·Joel Coffel, Eric Nuxoll

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