Design of a wideband multi-channel system for time reversal hyperthermia

International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group
Hana Dobšíček TrefnáMikael Persson

Abstract

To design and test a wideband multi-channel amplifier system for time reversal (TR) microwave hyperthermia, operating in the frequency range 300 MHz-1 GHz, enabling operation in both pulsed and continuous wave regimes. This is to experimentally verify that adaptation of the heating pattern with respect to tumour size can be realised by varying the operating frequency of the antennas and potentially by using Ultra-wideband (UWB) pulse sequences instead of pure harmonic signals. The proposed system consists of 12 identical channels driven by a common reference signal. The power and phase settings are applied with resolutions of 0.1 W and 0.1°, respectively. Using a calibration procedure, the measured output characteristics of each channel are interpolated using polynomial functions, which are then implemented into a system software algorithm driving the system feedback loop. The maximum output power capability of the system varies with frequency, between 90 and 135 W with a relative power error of ± 6%. A phase error in the order of ± 4° has been achieved within the entire frequency band. The developed amplifier system prototype is capable of accurate power and phase delivery, over the entire frequency band of the system. The out...Continue Reading

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Citations

Nov 20, 2012·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·R A M CantersG C van Rhoon
May 16, 2013·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Margarethus M PaulidesGerard C Van Rhoon
Mar 5, 2019·Physics in Medicine and Biology·Hana Dobsicek Trefna, Anna Ström
Dec 17, 2020·Physics in Medicine and Biology·Massimiliano Zanoli, Hana Dobšíček Trefná

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