Design of AIEgens for near-infrared IIb imaging through structural modulation at molecular and morphological levels.

Nature Communications
Yuanyuan LiBen Zhong Tang

Abstract

Fluorescence imaging in near-infrared IIb (NIR-IIb, 1500-1700 nm) spectrum holds a great promise for tissue imaging. While few inorganic NIR-IIb fluorescent probes have been reported, their organic counterparts are still rarely developed, possibly due to the shortage of efficient materials with long emission wavelength. Herein, we propose a molecular design philosophy to explore pure organic NIR-IIb fluorophores by manipulation of the effects of twisted intramolecular charge transfer and aggregation-induced emission at the molecular and morphological levels. An organic fluorescent dye emitting up to 1600 nm with a quantum yield of 11.5% in the NIR-II region is developed. NIR-IIb fluorescence imaging of blood vessels and deeply-located intestinal tract of live mice based on organic dyes is achieved with high clarity and enhanced signal-to-background ratio. We hope this study will inspire further development on the evolution of pure organic NIR-IIb dyes for bio-imaging.

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Citations

Oct 17, 2020·Research : a Science Partner Journal·Zonghai ShengBen Zhong Tang
Jun 10, 2020·Angewandte Chemie·Wenhan XuBen Zhong Tang
Nov 4, 2020·Chemistry : a European Journal·Francis L BuguisJoe B Gilroy
Aug 12, 2020·Angewandte Chemie·Zuhai Lei, Fan Zhang
May 21, 2020·Angewandte Chemie·Dingyuan YanBen Zhong Tang
Nov 17, 2020·Chemical Society Reviews·Guangxue FengDan Ding
Jan 13, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Juechen NiBen Zhong Tang
Mar 17, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Wang WangXiaomin Liu
Nov 7, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Tongxia JinXuhong Qian
Apr 10, 2021·ACS Applied Materials & Interfaces·Xuehong MinYue Sun
Apr 23, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Huihui ZouWei Han
May 12, 2021·Journal of Nanobiotechnology·Nan-Nan ZhangJian-Song Ji
Jun 25, 2021·Chemical Science·Yujia ZhengXuechuan Hong
Jun 25, 2021·Chemical Science·Shunjie LiuBen Zhong Tang
Jul 23, 2021·Chemical Communications : Chem Comm·Yuichi KitagawaYasuchika Hasegawa
Jul 30, 2021·The Journal of Physical Chemistry. B·Valentin Diez-CabanesMariachiara Pastore
Aug 14, 2020·Journal of the American Chemical Society·Chunyan LiQiangbin Wang
Sep 3, 2020·ACS Central Science·Shangfeng WangFan Zhang
Aug 21, 2020·ACS Applied Materials & Interfaces·Daoming ZhuKelong Fan
Aug 3, 2021·Chemistry : a European Journal·Zhicheng YangJianli Hua

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Methods Mentioned

BETA
fluorescence imaging
nanoprecipitation
dynamic
transmission electron microscopy

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