Design of artificial selenoenzymes based on macromolecular scaffolds

Macromolecular Bioscience
Xin HuangJunqiu Liu

Abstract

The selenoenzyme glutathione peroxidase has received increased attention as one of the antioxidative enzymes exerting important biological roles in living bodies. Over the past decades, much effort has been invested to mimic its catalytic behavior for understanding enzymatic catalytic mechanisms and also for developing potential medicines. A great number of artificial GPxs, ranging from small molecular compounds to macromolecular ones, have been designed and prepared by combining the concept of recognition and catalysis using chemical, biological and supramolecular strategies. In this article, we specify the development of artificial GPxs based on macromolecules as scaffolds, and discuss the power of reduced models in studying the bio-catalytic nature of selenoenzymes.

References

Jan 1, 1990·Annual Review of Biochemistry·T C Stadtman
Jun 1, 1972·Hoppe-Seyler's Zeitschrift für physiologische Chemie·L FlohéE Eichele
Jun 1, 1983·European Journal of Biochemistry·O EppA Wendel
Oct 1, 1995·General Pharmacology·T Schewe
Feb 15, 1994·Biochemical and Biophysical Research Communications·G M LuoJ C Shen
Jun 22, 1993·Biochemistry·R SyedD Hilvert
Mar 1, 1997·Experimental Physiology·H Sies
Jun 27, 1998·Biochemical and Biophysical Research Communications·J Q LiuJ C Shen
Jul 17, 1998·Current Opinion in Chemical Biology·K StuartS Lawson
Aug 17, 1999·Current Opinion in Biotechnology·G DeSantis, J B Jones
Oct 6, 2000·Biochimica Et Biophysica Acta·J LiuJ Shen
Nov 17, 2001·Chemical Reviews·D QiM D Distefano
Dec 12, 2001·Current Opinion in Chemical Biology·C M TannM D Distefano
Dec 19, 2001·Accounts of Chemical Research·R Wolfenden, M J Snider
Dec 26, 2001·Chemical Reviews·K Haupt, K Mosbach
Jan 10, 2002·Chemical Reviews·Günter Wulff
Mar 28, 1996·Chemical Reviews·Yukito MurakamiOsamu Hayashida
Feb 19, 2002·Chemical Reviews·Ronald Breslow, Steven D. Dong
Apr 5, 2002·Chembiochem : a European Journal of Chemical Biology·Xiaojun RenJiacong Shen
Apr 17, 2002·Accounts of Chemical Research·Govindasamy Mugesh, Harkesh B Singh
Mar 3, 2004·Angewandte Chemie·William B MotherwellBrian H Warrington
Mar 11, 2004·Chemical Reviews·Lara A Estroff, Andrew D Hamilton
May 27, 2004·Journal of the American Chemical Society·Xi ZhangZhiqiang Wang
Aug 26, 2004·Journal of the American Chemical Society·Xi ZhangJiacong Shen
Nov 19, 2004·Angewandte Chemie·Flavio ManeaPaolo Scrimin
Apr 9, 2005·BioFactors·Junji TeraoSatoshi Mohri
Apr 14, 2005·Chemical Reviews·Dennis M VriezemaRoeland J M Nolte
May 18, 2005·Accounts of Chemical Research·Xiyun Zhang, K N Houk

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Citations

Apr 5, 2014·Journal of Molecular Recognition : JMR·Michael J WhitcombeIan A Nicholls
Sep 22, 2015·ACS Applied Materials & Interfaces·Tianyu LiHuaping Xu
Dec 3, 2010·Chemical Society Reviews·Xin HuangJiacong Shen
Sep 14, 2012·Chemical Society Reviews·Zeyuan DongJunqiu Liu

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