Design of carboxymethyl chitosan-based heparin-mimicking cross-linked beads for safe and efficient blood purification

International Journal of Biological Macromolecules
Yilin WangChangsheng Zhao

Abstract

Safe and efficient carboxymethyl chitosan (CMC)-based heparin-mimicking cross-linked beads (CMC/PAMPS) as adsorbents for the clearance of low-density lipoprotein-cholesterol (LDL-c) in blood purification were prepared through hydrogen bonding interactions followed with in situ cross-linking with 2-acrylamido-2-methyl-1-propanesulfonicacid (AMPS). Fourier transform infrared spectra (FTIR), two-dimensional correlation FTIR spectroscopy (2D IR), thermal gravimetric analysis (TGA) and energy dispersive X-ray spectrometer (EDS) demonstrated the successful synthesis of CMC/PAMPS beads. The porous structures of the beads may contribute to the adsorption of toxins. Owing to their favorable hydrophilicity, when contacted with blood, the beads showed excellent hemocompatibility. The hemolysis ratios for all the beads were less than 5%, the thromboplastin time of CMC/PAMPS10 beads exceed 600 s, and they can suppress contact activation and complement activation effectively. Additionally, the beads have no obvious cytotoxicity with endothelial cells, thus could be used as a safe adsorbent for blood purification. Moreover, the CMC/PAMPS10 beads possessed a LDL-c adsorption capacity of 24.8 mg/g under static adsorption and a LDL-c adsorption ...Continue Reading

Citations

Dec 20, 2019·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Yilin WangChangsheng Zhao
Nov 30, 2019·International Journal of Biological Macromolecules·Jue ZhangChangsheng Zhao
Feb 14, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Yunhong LiuYugang Huang
Jan 20, 2021·ACS Biomaterials Science & Engineering·Mojtaba EnayatiAlireza Abbaspourrad
Aug 28, 2021·Journal of Chromatography. a·Guangshuai YaoLingyun Jia

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