Design of Engineered Cyclodextrin Derivatives for Spontaneous Coating of Highly Porous Metal-Organic Framework Nanoparticles in Aqueous Media

Nanomaterials
Giovanna CutroneA Vargas-Berenguel

Abstract

Nanosized metal-organic frameworks (nanoMOFs) MIL-100(Fe) are highly porous and biodegradable materials that have emerged as promising drug nanocarriers. A challenging issue concerns their surface functionalization in order to evade the immune system and to provide molecular recognition ability, so that they can be used for specific targeting. A convenient method for their coating with tetraethylene glycol, polyethylene glycol, and mannose residues is reported herein. The method consists of the organic solvent-free self-assembly on the nanoMOFs of building blocks based on β-cyclodextrin facially derivatized with the referred functional moieties, and multiple phosphate groups to anchor to the nanoparticles' surface. The coating of nanoMOFs with cyclodextrin phosphate without further functional groups led to a significant decrease of macrophage uptake, slightly improved by polyethylene glycol or mannose-containing cyclodextrin phosphate coating. More notably, nanoMOFs modified with tetraethylene glycol-containing cyclodextrin phosphate displayed the most efficient "stealth" effect. Mannose-coated nanoMOFs displayed a remarkably enhanced binding affinity towards a specific mannose receptor, such as Concanavalin A, due to the multi...Continue Reading

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Citations

Sep 27, 2019·Current Pharmaceutical Design·Romina MitarotondaMauricio C De Marzi
Mar 15, 2020·Materials·Huacheng ZhangJian Shen
Oct 13, 2020·Frontiers in Bioengineering and Biotechnology·Xue LiRuxandra Gref
Feb 13, 2021·ACS Applied Materials & Interfaces·Francisco J R MejíasFrancisco A Macías
Dec 19, 2020·Nanomaterials·Gonzalo Rivero-BarbarrojaJosé Manuel García Fernández
Apr 11, 2020·International Journal of Pharmaceutics·Jingwen QiuRuxandra Gref

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Methods Mentioned

BETA
biosensing
column chromatography
NMR
X-ray
isothermal titration calorimetry

Software Mentioned

Bruker
Igor Pro
Nika suite

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