Design of injectable organic-inorganic hybrid for bone tissue repair

Journal of Biomedical Materials Research. Part a
M DessìLuigi Ambrosio

Abstract

Injectable bone substitutes are rapidly gained success in tissue engineering applications for their less invasive surgical aspect. Here, the design and the characterization of a novel degradable paste of PCL reinforced with nanocrystals of hydroxyapatite have been presented aiming to mimic natural tissue. Nanohydroxyapatite has been successfully synthesized via sol-gel technique. Dynamic and steady state viscoelastic properties of the solutions and paste were investigated to control the kinetic of phase transition. Correspondingly, the morphology and composition were characterized via TEM, EDAX, and thermal analysis. Injection test underlines the completely ability of the paste of being injected without altering its features. Preliminary biological study showed that the composite paste is not cytotoxic. The synergistic rheological and biological properties, combined with the positive effect of chemical synthesis method indicate that the composite paste is very suitable as local bone substitute in low-load areas.

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Citations

Jun 1, 2013·Journal of Tissue Engineering and Regenerative Medicine·Vincenzo D'AntòLuigi Ambrosio
Jan 13, 2016·Journal of Tissue Engineering and Regenerative Medicine·M G RaucciL Ambrosio
Jul 23, 2013·Journal of Biomedical Materials Research. Part a·M DessìL Ambrosio
Oct 9, 2014·Journal of Biomedical Materials Research. Part a·M G RaucciL Ambrosio
Mar 10, 2018·Advanced Materials·Shanju ZhangChinedum O Osuji
Sep 13, 2018·Journal of Biomedical Materials Research. Part a·Ugo D'AmoraLuigi Ambrosio
Jun 3, 2020·Advanced Healthcare Materials·Maria Grazia RaucciLuigi Ambrosio
Dec 21, 2018·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Bo YuanLuigi Ambrosio
Feb 5, 2015·Journal of Materials Science. Materials in Medicine·Maria Grazia RaucciLuigi Ambrosio
Jun 4, 2020·Science and Technology of Advanced Materials·Muhammad SaleemChen Yougen
Oct 28, 2013·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Ki Hyun BaeMotoichi Kurisawa
Mar 5, 2019·Frontiers in Bioengineering and Biotechnology·Maria Grazia RaucciLuigi Ambrosio
Oct 20, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Alessandro JägerEliézer Jäger
Dec 18, 2012·Journal of Applied Biomaterials & Functional Materials·Maria Grazia RaucciLuigi Ambrosio

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