Feb 11, 2020

Design of multi epitope-based peptide vaccine against E protein of human COVID-19: An immunoinformatics approach

BioRxiv : the Preprint Server for Biology
Miysaa I. AbdelmageedAbdelrafie M. Makhawi

Abstract

Background: New endemic disease has been spread across Wuhan City, China on December 2019. Within few weeks, the World Health Organization (WHO) announced a novel coronavirus designated as coronavirus disease 2019 (COVID-19). In late January 2020, WHO declared the outbreak of a public-health emergency of international concern due to the rapid and increasing spread of the disease worldwide. Currently, there is no vaccine or approved treatment for this emerging infection; thus the objective of this study is to design a multi epitope peptide vaccine against COVID-19 using immunoinformatics approach. Method: Several techniques facilitating the combination of immunoinformatics approach and comparative genomic approach were used in order to determine the potential peptides for designing the T cell epitopes-based peptide vaccine using the envelope protein of 2019-nCoV as a target. Results: Extensive mutations, insertion and deletion were discovered with comparative sequencing in COVID-19 strain. Additionally, ten peptides binding to MHC class I and MHC class II were found to be promising candidates for vaccine design with adequate world population coverage of 88.5% and 99.99%, respectively. Conclusion: T cell epitopes-based peptide va...Continue Reading

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Mentioned in this Paper

Gene Products, env
Vaccines
Coronaviridae
World
Peptides
World Health Organization
Public Health Service
Gene Deletion
Profile (Lab Procedure)
Genomics

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