Design of Novel Perovskite-Based Polymeric Poly(l-Lactide-Co-Glycolide) Nanofibers with Anti-Microbial Properties for Tissue Engineering

Nanomaterials
Aleksander GóraShayanti Mukherjee

Abstract

: There is a growing need for anti-microbial materials in several biomedical application areas, such are hernia, skin grafts as well as gynecological products, owing to the complications caused by infection due to surgical biomaterials. The anti-microbial effects of silver in the form of nanoparticles, although effective, can be toxic to surrounding cells. In this study, we report, for the first time, a novel biomedical application of Ag0.3Na1.7La2Ti3O10-layered perovskite particles, blended with poly(L-lactide-co-glycolide) (PLGA), aimed at designing anti-microbial and tissue engineering scaffolds. The perovskite was incorporated in three concentrations of 1, 5, 10 and 15 w/w% and electrospun using dimethylformamide (DMF) and chloroform. The morphology of the resultant nanofibers revealed fiber diameters in the range of 408 to 610 nm by scanning electron microscopy. Mechanical properties of perovskite-based nanofibers also matched similar mechanical properties to human skin. We observed impressive anti-microbial activity, against Gram-negative, Gram-positive bacteria and even fungi, to Ag0.3Na1.7La2Ti3O10 in powder as well as nanofiber-incorporated forms. Furthermore, cytotoxicity assay and immunocytochemistry revealed that pe...Continue Reading

References

Jan 1, 1980·Archives of Dermatological Research·P G AgacheJ De Rigal
Sep 1, 1995·Biotechnic & Histochemistry : Official Publication of the Biological Stain Commission·J Kapuscinski
Apr 13, 2005·The Journal of Hospital Infection·S L PercivalD Russell
Jun 23, 2007·Angewandte Chemie·Andreas Greiner, Joachim H Wendorff
Feb 5, 2008·Applied and Environmental Microbiology·Woo Kyung JungYong Ho Park
Jul 9, 2010·Journal of the Royal Society, Interface·Rajeswari RavichandranSeeram Ramakrishna
Nov 18, 2010·Toxicology Mechanisms and Methods·Dhermendra K TiwariJ Behari
Jan 21, 2011·Tissue Engineering. Part a·Rajeswari RavichandranSeeram Ramakrishna
May 28, 2011·Journal of Materials Science. Materials in Medicine·Shayanti MukherjeeSeeram Ramakrishna
Jun 28, 2011·Journal of Biomedical Nanotechnology·Jingwu MaYan Huang
Jan 27, 2012·Macromolecular Bioscience·Rajeswari RavichandranSeeram Ramakrishna
Feb 14, 2012·Journal of Applied Microbiology·M K RaiA K Gade
Apr 12, 2012·Journal of Materials Science. Materials in Medicine·R KrishnanS Ramakrishna
Jul 7, 2012·Journal of Biomedical Nanotechnology·M Shamshi HassanMyung-Seob Khil
Nov 7, 2012·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Venugopal Jayarama ReddySeeram Ramakrishna
Jan 22, 2013·Macromolecular Bioscience·Rajeswari RavichandranSeeram Ramakrishna
Nov 23, 2013·European Journal of Microbiology & Immunology·Hagen FrickmannGerhard Dobler
Mar 5, 2014·International Journal of Molecular Sciences·Piergiorgio GentilePaul V Hatton
Dec 24, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Pushkar Kanhere, Zhong Chen
Jan 1, 2014·Brazilian Journal of Microbiology : [publication of the Brazilian Society for Microbiology]·Simin MohseniAhmad Asoodeh
May 24, 2015·Journal of Biomedical Nanotechnology·Yan HuangJingwu Ma
Aug 25, 2015·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Marina GimenoLluís Luján
Oct 27, 2015·Human & Experimental Toxicology·A GalandákováJ Ulrichová
Sep 27, 2016·International Journal of Molecular Sciences·Xi-Feng ZhangSangiliyandi Gurunathan
Apr 14, 2017·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Iolanda FrancoliniGianfranco Donelli

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Citations

Dec 24, 2021·ACS Applied Materials & Interfaces·Emanuele MaccaferriLoris Giorgini

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Methods Mentioned

BETA
scanning electron microscopy
infrared spectroscopy
X-ray
confocal microscopy

Software Mentioned

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Origin Pro
ImageJ

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