Design of PLGA-based depot delivery systems for biopharmaceuticals prepared by spray drying

International Journal of Pharmaceutics
Feng Wan, Mingshi Yang

Abstract

Currently, most of the approved protein and peptide-based medicines are delivered via conventional parenteral injection (intramuscular, subcutaneous or intravenous). A frequent dosing regimen is often necessary because of their short plasma half-lives, causing poor patient compliance (e.g. pain, abscess, etc.), side effects owing to typical peak-valley plasma concentration time profiles, and increased costs. Among many sustained-release formulations poly lactic-co-glycolic acid (PLGA)-based depot microparticle systems may represent one of the most promising approaches to provide protein and peptide drugs with a steady pharmacokinetic/pharmacodynamic profile maintained for a long period. However, the development of PLGA-based microparticle systems is still impeded by lack of easy, fast, effective manufacturing technologies. The aim of this paper is to review recent advances in spray drying, a one-step, continuous microencapsulation process, for manufacturing of PLGA-based depot microparticle systems with a focus on the recent efforts on understanding of the role of nozzle design in the microencapsulation of proteins/peptides, and the effect of critical solvent properties and process parameters on the critical quality attributes ...Continue Reading

References

Nov 15, 1991·Mechanisms of Ageing and Development·C Masters
Jun 20, 1997·Science·D A EdwardsR Langer
Jul 27, 1999·Journal of Microencapsulation·D F BainA Smith
Oct 16, 1999·Journal of Controlled Release : Official Journal of the Controlled Release Society·Y KawashimaT Hino
Aug 8, 2001·Journal of Controlled Release : Official Journal of the Controlled Release Society·K HanJ S Park
Mar 2, 2002·Science·I G LoscertalesA M Gañán-Calvo
Aug 30, 2002·Proceedings of the National Academy of Sciences of the United States of America·N TsapisD A Edwards
Mar 11, 2003·Biomacromolecules·Stefania G BaldursdóttirHanne H Tønnesen
Mar 12, 2003·Journal of Controlled Release : Official Journal of the Controlled Release Society·Shigeyuki TakadaTomofumi Kurokawa
Aug 23, 2003·Journal of Controlled Release : Official Journal of the Controlled Release Society·K SurendrakumarJ A Blair
Nov 26, 2003·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yoon YeoKinam Park
Feb 6, 2004·Journal of Colloid and Interface Science·Jianjun WangChi-Hwa Wang
Oct 27, 2004·International Journal of Pharmaceutics·S SchenderleinB W Müller
Nov 30, 2004·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yoon Yeo, Kinam Park
Apr 2, 2005·Nature Reviews. Drug Discovery·Sven Frokjaer, Daniel E Otzen
Oct 18, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Naumana R Rabbani, Peter C Seville
Oct 29, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Fude CuiYing Guan
Nov 22, 2005·Expert Opinion on Drug Delivery·Yi Shi, Luk Chiu Li
Jan 18, 2006·International Journal of Pharmaceutics·Jin-Tian HeHou-Yan Song
Aug 22, 2006·Current Pharmaceutical Biotechnology·T R Shantha KumarS K Nachaegari
Oct 20, 2007·Journal of Colloid and Interface Science·Jingwei XieChi-Hwa Wang
Nov 28, 2007·Pharmaceutical Research·Reinhard Vehring
Dec 29, 2007·International Journal of Pharmaceutics·A GiteauJ P Benoit
Mar 4, 2008·International Journal of Pharmaceutics·Hyejung MokTae Gwan Park
May 1, 2008·AAPS PharmSciTech·Mahavir ChouguleAmbikanandan Misra
Jun 3, 2008·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Hyejung Mok, Tae Gwan Park
Jul 16, 2008·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yan GengTuo Jin
Jul 16, 2008·International Journal of Pharmaceutics·Christian Wischke, Steven P Schwendeman
Aug 30, 2008·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Morten Jonas MaltesenMarco van de Weert
Jan 22, 2009·Journal of Controlled Release : Official Journal of the Controlled Release Society·Francesca UngaroMaria Immacolata La Rotonda
Jun 9, 2009·International Journal of Pharmaceutics·Eva WulstenGeoffrey Lee
Oct 20, 2009·International Journal of Pharmaceutics·Dongmei CunHanne Mørck Nielsen
Oct 21, 2009·Journal of Controlled Release : Official Journal of the Controlled Release Society·Ditte Marie Krohn JensenCamilla Foged
Nov 19, 2009·The AAPS Journal·Rajesh Kumar, Michael J Palmieri
Mar 12, 2010·Journal of Controlled Release : Official Journal of the Controlled Release Society·V SalujaW L J Hinrichs
Mar 30, 2010·Expert Opinion on Drug Delivery·Leena PeltonenJouni Hirvonen
Mar 30, 2010·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yi-Hsuan LeeDa-Ren Chen
May 25, 2010·Journal of Controlled Release : Official Journal of the Controlled Release Society·Mingli YeKinam Park
Aug 21, 2010·Journal of Food Science·Jerrad Legako, Nurhan Turgut Dunford
Sep 11, 2010·Nature Biotechnology·Gary Walsh

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Citations

Mar 15, 2018·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Parker W Lee, Jonathan K Pokorski
Apr 6, 2018·Drug Development and Industrial Pharmacy·Ariane J Sousa-BatistaMaria Inês Ré
Dec 24, 2018·Drug Development and Industrial Pharmacy·Mohammed M MehannaHoda A Elmartadny
Oct 16, 2020·Progress in Biomaterials·Elena LagrecaRaffaele Vecchione
Oct 19, 2017·Journal of Pharmaceutical Sciences·Nattawut LeelakanokAliasger Salem
Apr 17, 2021·ACS Pharmacology & Translational Science·Vicki WangYuan-Hao Chen
Nov 15, 2019·International Journal of Pharmaceutics·F TamaniJ Siepmann
Apr 13, 2021·Advanced Drug Delivery Reviews·Dongmei CunMingshi Yang
Sep 14, 2018·ACS Applied Materials & Interfaces·Feng WanMingshi Yang

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