Design of Pyrene-Fatty Acid Conjugates for Real-Time Monitoring of Drug Delivery and Controllability of Drug Release

ACS Omega
Keita HayashiHiroshi Umakoshi

Abstract

Fluorescence probes are usually employed to analyze pharmacokinetics of drug carriers; however, this method using usual probes is not suitable to monitor drug carriers in detail because fluorescence spectra do not change by the disruption of drug carriers. In this study, pyrene-fatty acid conjugates were investigated as probes to monitor the state of drug carriers in real time. 1-Pyrenemethanol was conjugated with fatty acids, such as lauric acid, stearic acid, and behenic acid, and the conjugates were stirred in ethanol, resulting in the formation of submicron particles; these particles exhibited excimer emission. When J774.1 and Colon 26 cells were treated with these particles, the associated fluorescence spectra shifted from excimer emission to monomer emission. Moreover, the degree of change was controlled by the type of fatty acid. These results support the design of drug carriers that can be used to monitor pharmacokinetics in real time and to control the disruption time.

References

Dec 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·H S BangaS E Rittenhouse
Oct 24, 1995·Proceedings of the National Academy of Sciences of the United States of America·G LiP D Stahl
Apr 11, 1996·Nature·D D Lasic
Jul 8, 1997·Proceedings of the National Academy of Sciences of the United States of America·V PatkiS Corvera
Apr 2, 1998·Trends in Biotechnology·K A Giuliano, D L Taylor
Mar 4, 2000·Advanced Drug Delivery Reviews·M P Murphy, R A Smith
Aug 9, 2002·Journal of the American Chemical Society·Toshiyuki MoriuchiToshikazu Hirao
Dec 16, 2004·Chemical Communications : Chem Comm·Simon M Langenegger, Robert Häner
Nov 23, 2005·Proceedings of the National Academy of Sciences of the United States of America·Chaoyong James YangWeihong Tan
Mar 17, 2010·Journal of Controlled Release : Official Journal of the Controlled Release Society·Gaurav SahayAlexander V Kabanov
Dec 26, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Zia ur RehmanDick Hoekstra
Oct 1, 2013·Journal of Controlled Release : Official Journal of the Controlled Release Society·Mark J ErnstingShyh-Dar Li
Jan 17, 2014·Journal of Chemical Biology·Christopher P Toseland
Jun 20, 2014·Chemical Communications : Chem Comm·Shinaj K RajagopalMahesh Hariharan
Jul 1, 2014·ACS Applied Materials & Interfaces·Javier LinaresM Teresa Portolés
Sep 10, 2014·Chemical Society Reviews·Scott Fleming, Rein V Ulijn
Jan 13, 2015·Advanced Drug Delivery Reviews·Prarthana V RewatkarMarie-Odile Parat
May 21, 2015·Colloids and Surfaces. B, Biointerfaces·Steven KirkhamJanne Ruokolainen
Oct 7, 2015·Bioconjugate Chemistry·Herdeline Ann M Ardoña, John D Tovar
Feb 16, 2016·Advanced Drug Delivery Reviews·Stefanie D KrämerSara Belli
Apr 26, 2016·Advanced Drug Delivery Reviews·Ana CostaBruno Sarmento
Jul 13, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Qizhi HuTwan Lammers

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Citations

Oct 14, 2020·European Journal of Medicinal Chemistry·Alicia BauduinPaul-Alain Jaffrès

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Methods Mentioned

BETA
X-ray
differential scanning calorimetry
Raman spectroscopy
Fluorescence microscopy
Fluorescence
Assay

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