Design of [R-(Z)]-(+)-alpha-(methoxyimino)-1-azabicyclo[2.2.2]octane-3-acetonitri le (SB 202026), a functionally selective azabicyclic muscarinic M1 agonist incorporating the N-methoxy imidoyl nitrile group as a novel ester bioisostere

Journal of Medicinal Chemistry
S M BromidgeG J Riley

Abstract

Loss of cholinergic function is believed to be implicated in the cognitive decline associated with senile dementia of the Alzheimer type (SDAT). The disease is characterized by progressive loss of muscarinic receptors located on nerve terminals while postsynaptic muscarinic M1 receptors appear to remain largely intact. Muscarinic agonists acting directly on postsynaptic receptors offer the prospect of countering the cholinergic deficit in SDAT. This study describes a novel series of azabicyclic muscarinic agonists, which incorporate an oxime ether or modified oxime ether group as an ester bioisostere. Modification of the oxime ether function by the introduction of electron withdrawing groups led to the finding that the (Z)-N-methoxy imidoyl nitrile group serves as a stable methyl ester bioisostere. This culminated in the discovery of the quinuclidinyl N-methoxy imidoyl nitrile R-(+)-(Z)-5g which is a functionally selective muscarinic M1 partial agonist currently in phase III clinical trials for the treatment of SDAT. The selective profile of R-(+)-(Z)-5g can be rationalized in terms of the relative affinity of the compound at muscarinic receptor subtypes, the degree of agonist efficacy, and brain penetrancy.

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Citations

Apr 15, 2004·Bioorganic & Medicinal Chemistry·Myoung Goo KimHarold Kohn
Jun 18, 2002·European Journal of Pharmacology·Weng-Keong LokeMei-Lin Go
Feb 15, 2002·Bioorganic & Medicinal Chemistry Letters·Frank NavasM Jeffrey Gobel
Dec 12, 2001·Bioorganic & Medicinal Chemistry·Brinda SomanadhanMei-Lin Go
Sep 2, 2010·Journal of Medicinal Chemistry·Fraser F FlemingBrian C Shook
Oct 19, 2000·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·A LeuschW Roth

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