Design of salbutamol EOP tablets from pharmacokinetics parameters

Pharmaceutical Development and Technology
Nuttanan SinchaipanidAmpol Mitrevej

Abstract

Salbutamol elementary osmotic pump (EOP) tablets were developed, and fundamental variables affecting their release characteristics were evaluated. The effects of film thickness and compression force on drug release from the tablets containing fixed amount of sodium chloride used as osmogent were evaluated. The core tablets were directly compressed at four compression forces and coated with 3% wt/vol cellulose acetate in acetone to levels of 2%, 3%, and 4% wt/wt. Coated tablets were drilled with CO2 laser beam to form drug delivery orifice of approximately 400 microm in diameter. The drug release was found to follow zero order fashion. The release rate decreased with the increased film thickness and was not affected by the compression force or porosity. The tablets coated to 3% and 4% levels exhibited the release rates within the range calculated from pharmacokinetic data. To illustrate the effect of osmogent content, the tablets were prepared at four osmogent levels and compressed at a constant compression force. The core tablets were coated to a level of 3% wt/wt. The release rate was initially increased with osmogent content and then decreased. At higher osmogent contents, the drug fraction in soluble component was decreased ...Continue Reading

References

Dec 1, 1975·Journal of Pharmaceutical Sciences·F Theeuwes
Dec 24, 1998·Journal of Controlled Release : Official Journal of the Controlled Release Society·M V VelascoA R Rajabi-Siahboomi
May 29, 2000·Journal of Controlled Release : Official Journal of the Controlled Release Society·L LiuH B Lee

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Citations

Apr 12, 2011·AAPS PharmSciTech·Ahmed Abd-ElbaryAhmed Adel Alaa-Eldin
Mar 24, 2009·Acta Pharmaceutica : a Quarterly Journal of Croatian Pharmaceutical Society and Slovenian Pharmaceutical Society, Dealing with All Branches of Pharmacy and Allied Sciences·Pramod KumarBrahmeshwar Mishra
Mar 23, 2011·Drug Development and Industrial Pharmacy·Siracha TuntikulwattanaAmpol Mitrevej
Jul 16, 2009·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Vincent MalaterreRobert Gurny
Jan 19, 2011·International Journal of Pharmaceutics·Muhammad Naeem AamirAli Nokhodchi
Sep 16, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Mei-Li LaracuenteKevin J McHugh

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