Design of the DRAGET Study: a multicentre controlled diagnostic study to assess the detection of acute rejection in patients with heart transplant by means of T2 quantification with MRI in comparison to myocardial biopsies

BMJ Open
Laurent BonnemainsJacques Felblinger

Abstract

Patients with heart transplant are screened for silent graft rejection by recurrent endomyocardial biopsies. MRI can detect the presence of oedema non-invasively by quantitatively measuring changes of the transverse relaxation time T2 in the myocardium. Several monocentric studies have shown that T2 quantification could help detect graft rejection in a less invasive way. DRAGET is a national multicentre diagnostic study designed to prove that T2 quantification by MRI can detect graft rejection. 190 patients from 10 centres will undergo T2 quantification and endomyocardial biopsy, within 24 h, 4 to 6 times during the first year after transplantation. T2 will be computed by analysing a sequence of 10 images obtained from a short-axis slice. Specific phantoms will be used to calibrate the T2 quantification on each MR scanner to cope with the different equipment (different vendors, magnetic field strength, etc). Specific pads with known T2 will also be used during each examination and provide a quality check to cope with the different experimental conditions (temperature, etc). All MRI and biopsy data will be reinterpreted in our centre and reproducibility will be assessed. The primary outcome will be sensitivity and specificity of...Continue Reading

References

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Citations

Jan 19, 2016·Archives of Cardiovascular Diseases·Laurent BonnemainsFreddy Odille
Jun 4, 2016·Transplant International : Official Journal of the European Society for Organ Transplantation·Laurent BonnemainsJacques Felblinger
Mar 18, 2017·Current Opinion in Cardiology·Maria G Crespo-LeiroDavid Couto-Mallon
Aug 30, 2018·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Emmanuelle VermesLaurent Brunereau
May 13, 2017·Heart Failure Reviews·A S LotaR H Mohiaddin
May 25, 2021·CJC Open·Omid Kiamanesh, Mustafa Toma

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Methods Mentioned

BETA
biopsies
biopsy

Software Mentioned

DRAGET

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