Design of the economic evaluation for the Interventional Management of Stroke (III) trial.

International Journal of Stroke : Official Journal of the International Stroke Society
Patrick MauldinInterventional Management of Stroke III Investigators

Abstract

Stroke is a common and costly condition where an effective early treatment may be expected to affect patients' future quality of life, the cost of acute medical treatment, and the cost of rehabilitation and any supportive care needed for their remaining lifetime. To assist in informing discussions on early adoption of potential treatments, economic analyses should accompany investigations that seek to improve outcomes for stroke patients. The primary aim is to assess whether i.v./i.a. rt-PA therapy is cost-effective at 3 months compared with i.v. rt-PA, and provides cost-savings or is cost-neutral by 12 months. Design Cost-effectiveness of the two treatment arms will be measured at months 3, 6, 9, and 12. Cost-effectiveness will be calculated using 1.standard cost-effectiveness methodology (incremental cost-effectiveness ratios), and 2.an econometric model to assess multiple outcome measures while controlling for multiple subject and treatment-related factors that are known to affect both outcomes and costs. Total cost for the initial hospitalization of treating stroke subjects randomized to either i.v./i.a. or i.v. rt-PA treatment arms will be measured, as will differences in types of resource utilization over 12 months betwee...Continue Reading

References

Jul 1, 1995·Health Economics·P Dolan, C Gudex
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Mar 16, 2004·Lancet·Werner HackeUNKNOWN NINDS rt-PA Study Group Investigators
Apr 1, 1996·Environmental Health and Preventive Medicine·Y KiryuT Kawada

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Citations

Jun 1, 2012·Revue neurologique·D CalvetUNKNOWN French Society of Intensive Care
Jun 13, 2013·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Mark A EckertWeian Zhao
May 10, 2017·Journal of the American Heart Association·Kit N SimpsonUNKNOWN Interventional Management of Stroke (IMS) III Investigators
May 31, 2014·Stroke; a Journal of Cerebral Circulation·Kit N SimpsonUNKNOWN IMS III Investigators
Oct 12, 2010·The Cochrane Database of Systematic Reviews·Killian O'RourkePeter J Kelly
Apr 11, 2015·Stroke; a Journal of Cerebral Circulation·Yuko Y PaleschUNKNOWN Interventional Management of Stroke III Investigators
May 3, 2020·Transfusion·Rachael A CallcutUNKNOWN PROPPR Study Group

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Methods Mentioned

BETA
medical procedure

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