Design, Optimization and Characterization of a Transfersomal Gel Using Miconazole Nitrate for the Treatment of Candida Skin Infections

Pharmaceutics
Mona QushawyShady Swidan

Abstract

Miconazole nitrate (MIC) is an antifungal drug used for treatment of superficial fungal infections. However, it has low skin permeability. Hence, the objective of this study was to prepare miconazole nitrate using Transfersomes to overcome the barrier function of the skin. MIC Transfersomes were prepared using a thin lipid film hydration technique. The prepared Transfersomes were evaluated with respect to entrapment efficiency (EE%), particle size, and quantity of in vitro drug released to obtain an optimized formulation. The optimized formulation of MIC Transfersomes was incorporated into a Carbapol 934 gel base which was evaluated in comparison with a marketed product (Daktarin® cream 2%) for drug content, pH, spreadability, viscosity, in vitro permeation, and in vitro and in vivo antifungal activity. The prepared MIC Transfersomes had a high EE% ranging from (67.98 ± 0.66%) to (91.47 ± 1.85%), with small particle sizes ranging from (63.5 ± 0.604 nm) to (84.5 ± 0.684 nm). The in vitro release study suggested that there was an inverse relationship between EE% and in vitro release. The kinetic analysis of all release profiles was found to follow Higuchi's diffusion model. All independent variables had a significant effect on th...Continue Reading

References

Jul 6, 2010·International Journal of Pharmaceutics·Ghada M El ZaafaranyNahed D Mortada
Jul 17, 2012·International Journal of Pharmaceutics·Wen-sheng ZhengYu-jia Zhang
Jul 28, 2012·Journal of Advanced Pharmaceutical Technology & Research·Reshmy Rajan, Deepa T Vasudevan
Apr 24, 2013·Journal of Liposome Research·Mona BashaGhada E A Awad
Feb 1, 2014·Journal of Liposome Research·Jayamanti PanditNarendra Kumar Jain
Apr 1, 2015·Journal of Materials Science. Materials in Medicine·Fang GuoNan Li
May 1, 2015·Current Pharmaceutical Design·Nida AkhtarKamla Pathak
Feb 13, 2016·International Journal of Nanomedicine·Bader Mubarak Aljaeid, Khaled Mohamed Hosny
Jul 5, 2016·International Journal of Pharmaceutics·Silvia Mir-PalomoAmparo Ruiz Saurí
May 20, 2017·International Journal of Pharmaceutics·Menna M AbdellatifMahmoud A F Khalil

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Citations

Nov 7, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mona QushawyAli Nasr
Sep 13, 2020·Pharmaceutics·Shakthi Apsara Thejani OpathaRomchat Chutoprapat
Nov 5, 2019·International Journal of Pharmaceutics·Raquel Fernández-GarcíaDolores R Serrano
Mar 25, 2021·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·S RamkanthDinesh Babu
Jul 2, 2021·Pharmaceutical Development and Technology·Somayeh TaymouriJaleh Varshosaz
Jul 31, 2021·Daru : Journal of Faculty of Pharmacy, Tehran University of Medical Sciences·Ravindra PandeyBina Gidwani
Aug 15, 2021·International Journal of Pharmaceutics·Ruma MajiThirumala Govender
Oct 29, 2021·Nanomedicine·Pablo OyarzúnFrancisco Arriagada
Aug 6, 2020·Current Drug Delivery·Ritika Gupta, Amrish Kumar
Oct 19, 2020·Current Pharmaceutical Design·Drashti Patel, Bappaditya Chatterjee

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Methods Mentioned

BETA
dynamic light scattering
Infrared Spectroscopy
Scanning

Software Mentioned

Statgraphics ( R )
statgraphic plus
SPSS

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