Design, spectral characterization, thermal, DFT studies and anticancer cell line activities of Co(II), Ni(II) and Cu(II) complexes of Schiff bases derived from 4-amino-5-(pyridin-4-yl)-4H-1,2,4-triazole-3-thiol

Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
Prateek TyagiDeepak Yadav

Abstract

A series of two biologically active Schiff base ligands L(1), L(2) have been synthesized in equimolar reaction of 4-amino-5-(pyridin-4-yl)-4H-1,2,4-triazole-3-thiol with thiophene-2-carbaldehyde and furan-2-carbaldehyde. The synthesized Schiff bases were used for complexation with different metal ions like Co(II), Ni(II) and Cu(II) by using a molar ratio of ligand: metal as 1:1 and 2:1. The characterization of Schiff bases and metal complexes was done by (1)H NMR, UV-Vis, TGA, IR, mass spectrometry and molar conductivity studies. The in DFT studies the geometries of Schiff bases and metal complexes were fully optimized with respect to the energy using the 6-31+g(d,p) basis set. On the basis of the spectral studies an octahedral geometry has been assigned for Co(II), Ni(II) and Cu(II) complexes. The effect of these complexes on proliferation of human breast cancer cell line (MCF-7) and human hepatocellular liver carcinoma cell line (Hep-G2) were studied and compared with those of free ligand. The anticancer cell line results reveal that all metal complexes show moderate to significant % cytotoxicity on cell line HepG2 and MCF-7.

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Feb 5, 2013·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Sulekh ChandraNeesha Yadav
Aug 28, 2013·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Monika TyagiPrateek Tyagi
Jul 12, 2014·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Prateek TyagiB S Saraswat

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Citations

Mar 5, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Da-Chuan LiuZhe-Shan Quan
May 26, 2016·Journal of Fluorescence·Bandar A Babgi, Asma Alzahrani
May 8, 2020·Anti-cancer Agents in Medicinal Chemistry·Garima Matela
Jun 18, 2021·European Journal of Medicinal Chemistry·Wardha ZafarZahid H Chohan
Mar 1, 2018·Langmuir : the ACS Journal of Surfaces and Colloids·Zhigang YinSultan Ahmed Khoso

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