Design strategy of optical probes for tumor hypoxia imaging.

Science China. Life Sciences
Fengfeng XueHangrong Chen

Abstract

Clinical manifestations of tumors indicate that malignant phenotypes developing in the hypoxic microenvironment lead to resistance to cancer treatment, rendering chemotherapy, radiotherapy, and photodynamic therapy less sensitive and effective in patients with tumor. Visualizing the oxygen level in the tumor environment has garnered much attention due to its implications in precision tumor therapy. Following the rapid development of biomaterials in nanotechnology, various nanomaterials have been designed to visualize the oxygen levels in tumors. Here, we review recent research on detecting oxygen levels in solid tumors for tumor hypoxia imaging. To monitor the hypoxic level of tumors, two main strategies were investigated: directly detecting oxygen levels in tumors and monitoring the hypoxia-assisted reduced microenvironment. We believe that hypoxia as a tumor-specific microenvironment can be a breakthrough in the clinical treatment of tumors.

References

Jun 6, 1995·Proceedings of the National Academy of Sciences of the United States of America·G L WangG L Semenza
Apr 3, 2001·Nature Biotechnology·R Weissleder
Jun 27, 2002·Current Urology Reports·Aristotelis G AnastasiadisRalph Buttyan
Aug 30, 2003·Oncogene·Nicholas C DenkoAmato J Giaccia
Dec 10, 2003·Cancer Science·Shinae Kizaka-KondohMasahiro Hiraoka
May 12, 2004·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·M QuinteroP A Brennan
Jun 2, 2004·Nature Reviews. Cancer·J Martin Brown, William R Wilson
Jul 20, 2004·Nature Biotechnology·Xiaohu GaoShuming Nie
Oct 28, 2004·Journal of the American Chemical Society·Tasuku UenoTetsuo Nagano
Apr 2, 2005·Nature Reviews. Immunology·Jacques Banchereau, A Karolina Palucka
Apr 28, 2006·Nature·Janine T ErlerAmato J Giaccia
May 26, 2006·Nature·Jacques PouysségurNathalie M Mazure
Jan 16, 2007·Nature Reviews. Cancer·Adriana Albini, Michael B Sporn
Apr 19, 2007·Cancer Metastasis Reviews·Peter Vaupel, Arnulf Mayer
Mar 29, 2008·Stroke; a Journal of Cerebral Circulation·Masashi TakasawaJean-Claude Baron
Jul 30, 2008·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Olga S FinikovaSergei A Vinogradov
Sep 2, 2008·Nature Reviews. Drug Discovery·Mark E DavisDong M Shin
Jan 15, 2009·Nature Reviews. Cancer·Nicholas C Denko
Mar 13, 2010·Future Oncology·William A Denny
Apr 2, 2010·Chemical Reviews·Mikhail Y Berezin, Samuel Achilefu
Oct 29, 2010·Journal of the American Chemical Society·Kazuki KiyoseTetsuo Nagano
Apr 7, 2011·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Nadine Rohwer, Thorsten Cramer
Feb 22, 2012·The Journal of Cell Biology·Pengfei LuZena Werb
May 25, 2012·Journal of Microscopy·W Becker
Jun 14, 2012·Clinical & Experimental Metastasis·Janice A Nagy, Harold F Dvorak
Nov 2, 2012·Cancer Metastasis Reviews·Yan MaoJianhua Wang
Nov 15, 2012·Nature Reviews. Clinical Oncology·Michael R HorsmanJens Overgaard
Feb 20, 2013·Journal of Cell Science·Frances R BalkwillThorsten Hagemann
Jun 15, 2013·Advanced Materials·Jiang LiQing Huang
Jun 19, 2013·Chemical Society Reviews·Dmitri B Papkovsky, Ruslan I Dmitriev
Aug 13, 2013·Cancer Science·Kyoko HidaYasuhiro Hida
Sep 21, 2013·Nature·Melissa R Junttila, Frederic J de Sauvage
Oct 16, 2013·Angewandte Chemie·Wen PiaoKenjiro Hanaoka
Dec 3, 2013·Biomaterials·Thavasyappan ThambiJae Hyung Park
Feb 21, 2014·Angewandte Chemie·F PercheV P Torchilin
May 16, 2014·Nature Reviews. Cancer·Daniele M GilkesDenis Wirtz
Nov 6, 2014·Nature Reviews. Molecular Cell Biology·Janna K MouwValerie M Weaver
Dec 21, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Iftikhar Ali KhawarHyo-Jeong Kuh
Apr 30, 2015·Journal of the American Chemical Society·Yuhao LiFuyou Li

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Citations

Dec 29, 2020·Science China. Life Sciences·Qingming Luo

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