Design, synthesis, and anti-influenza viral activities of 1,3-diarylprop-2-en-1-ones: a novel class of neuraminidase inhibitors

Archives of Pharmacal Research
Mayank KingerSeung Dae Yang

Abstract

A series of 1,3-diarylprop-2-en-1-one derivatives 3a-v have been synthesized and evaluated for their ability to inhibit neuraminidase (NA). Among the prepared compounds, the less lipophilic derivative 3k showed the most potent in vitro inhibitory activity against NA with an IC(50) value of 1.5 μM.

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Citations

Aug 1, 2012·Current Opinion in Virology·Erik De Clercq
Apr 25, 2017·Acta Crystallographica. Section E, Crystallographic Communications·Gabriela Porto de OliveiraAdriano Bof de Oliveira
May 28, 2015·Archives of Pharmacal Research·Seung-Jin JungYong Dae Park

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