Design, synthesis, and antifungal activities of novel triazole derivatives containing the benzyl group

Drug Design, Development and Therapy
Kehan XuYuanying Jiang

Abstract

In previous studies undertaken by our group, a series of 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-substituted-2-propanols (1a-r), which were analogs of fluconazole, was designed and synthesized by click chemistry. In the study reported here, the in vitro antifungal activities of all the target compounds were evaluated against eight human pathogenic fungi. Compounds 1a, 1q, and 1r showed the more antifungal activity than the others.

Citations

Jun 23, 2019·Pest Management Science·Fabrizio AranitiBartolo Gabriele
Jun 8, 2021·Frontiers in Chemistry·Agnieszka StaśkiewiczRafal Latajka

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BETA
nuclear magnetic resonance

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