Design, synthesis and antimalarial activity of benzene and isoquinoline sulfonamide derivatives

Bioorganic & Medicinal Chemistry Letters
Maloy Kumar ParaiSunil Kumar Puri

Abstract

A new series of benzene and isoquinoline sulfonamide derivatives were synthesized by nucleophilic displacement reaction on benzene and isoquinoline sulfonyl chlorides by substituted amines (primary and secondary). The title compounds were evaluated for antimalarial activity against Plasmodium falciparum in vitro and showed MIC in the range of 2-50 microg/mL.

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Related Concepts

Antimalarials
Benzene
Isoquinolines
Plasmodium falciparum
Sulfonamides
Drug Modeling

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