Design, synthesis and antimalarial screening of some hybrid 4-aminoquinoline-triazine derivatives against pf-DHFR-TS

Experimental Parasitology
Supriya SahuHans Raj Bhat

Abstract

Existing antifolate antimalarial drugs have shown resistance due to the mutations at some amino acid positions of Plasmodium falciparum DHFR-TS. In the present study, to overcome this resistance, a new series of hybrid 4-aminoquinoline-triazine derivatives were designed and docked into the active site of Pf-DHFR-TS (PDB i.d. 1J3K) using validated CDOCKER protocol. Binding energy was calculated by applying CHARMm forcefield. Binding energy and the pattern of interaction of the docked compounds were analysed. Fifteen compounds were selected for synthesis based on their binding energy values and docking poses. Synthesized compounds were characterised by FTIR, (1)H NMR, (13)C NMR, mass spectroscopy and were screened for antimalarial activity against 3D7 strain of Plasmodium falciparum.

References

Jan 5, 2002·Trends in Parasitology·C H SibleyA M Nzila
Jun 3, 2004·Nature Reviews. Drug Discovery·David A FidockSolomon Nwaka
Feb 25, 2005·Bioorganic & Medicinal Chemistry·V Raja SolomonS B Katti
Apr 23, 2005·Acta Tropica·John E Hyde
Oct 27, 2007·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Carlos A M AfonsoAndreia de A Rosatella
Oct 28, 2008·Bioorganic & Medicinal Chemistry Letters·Ashok KumarPrem M S Chauhan
Nov 17, 2009·Bioorganic & Medicinal Chemistry Letters·Sunny ManoharDiwan S Rawat
Jan 5, 2011·European Journal of Medicinal Chemistry·Ashok KumarPrem M S Chauhan

❮ Previous
Next ❯

Citations

Nov 21, 2019·Anti-cancer Agents in Medicinal Chemistry·Tarawanti VermaNitin Bansal
Jun 25, 2020·Drug Development Research·Parteek PrasherKamal Dua
Oct 9, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sibusiso Alven, Blessing Aderibigbe
Mar 20, 2019·Mini Reviews in Medicinal Chemistry·Akranth MarellaMd Mumtaz Alam
Mar 25, 2021·Archiv der Pharmazie·Saumya SinghUdaya P Singh

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.