Design, synthesis, and biological evaluation of a potent, PKC selective, B-ring analog of bryostatin

Organic Letters
Paul A Wender, Vishal A Verma

Abstract

[structure: see text] The first member of a new class of five-membered B-ring analogs of bryostatin has been synthesized and tested for its ability to bind and translocate protein kinase C (PKC). This synthesis extends the utility of our previously introduced macrotransacetalization strategy to the formation of five-membered dioxolane B-ring analogs. This analog exhibits potent, single-digit nanomolar affinity to PKC and selectively translocates novel PKC isozymes.

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Citations

Feb 14, 2008·Cancer Chemotherapy and Pharmacology·Geoffrey Y KuGary K Schwartz
Dec 28, 2007·Accounts of Chemical Research·Paul A WenderThomas H Pillow
May 31, 2011·Journal of the American Chemical Society·Paul A Wender, Adam J Schrier
Jul 26, 2011·Journal of the American Chemical Society·Yu LuMichael J Krische
Mar 19, 2011·Proceedings of the National Academy of Sciences of the United States of America·Paul A WenderVishal A Verma
Jul 1, 2008·Expert Opinion on Drug Discovery·Stephen HarrisonDirk Mendel
May 20, 2017·Pharmaceuticals·Marta RuiSimona Collina
Mar 29, 2014·Chemical Record : an Official Publication of the Chemical Society of Japan ... [et Al.]·Kazuhiro Irie, Ryo C Yanagita
Feb 10, 2018·Chembiochem : a European Journal of Chemical Biology·Thomas J CumminsGary E Keck
Apr 1, 2010·Chemistry, an Asian Journal·Karl J Hale, Soraya Manaviazar
Nov 16, 2010·Angewandte Chemie·Alex M Szpilman, Erick M Carreira
Apr 1, 2011·Israel Journal of Chemistry·Paul A WenderAdam J Schrier
Sep 11, 2014·Journal of the American Chemical Society·Matthew B KraftGary E Keck

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