Design, synthesis, and biological evaluation of a novel series of quercetin diacylglucosides as potent anti-MRSA and anti-VRE agents

Bioorganic & Medicinal Chemistry Letters
Abugafar M L HossionKenji Sasaki

Abstract

A series of novel quercetin diacylglucosides were designed and first synthesized by Steglich esterification on the basis of MRSA strains inhibiting natural compound A. The in vitro inhibition of different multi-drug resistant bacterial strains and Escherichia coli DNA gyrase B was investigated. In the series, compound 10h was up to 128-fold more potent against vancomycin-resistant enterococci and more effective than A, which represents a promising new candidate as a potent anti-MRSA and anti-VRE agent.

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Nov 18, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·Supatcharee SiriwongGriangsak Eumkeb
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