Design, synthesis and biological evaluation of potent NAD+-dependent DNA ligase inhibitors as potential antibacterial agents. Part 2: 4-amino-pyrido[2,3-d]pyrimidin-5(8H)-ones

Bioorganic & Medicinal Chemistry Letters
Tiansheng WangPaul S Charifson

Abstract

A series of 4-amino-pyrido[2,3-d]pyrimidin-5(8H)-ones were designed and synthesized as a novel class of inhibitors of NAD(+)-dependent DNA ligase that possess potency against Gram-positive bacteria.

References

Apr 1, 2010·Expert Opinion on Drug Discovery·Robert V Swift, Rommie E Amaro

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Citations

May 14, 2014·Analytical and Bioanalytical Chemistry·Eva StejskalováMiroslav Fojta
Jan 21, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Malgorzata Korycka-MachalaJaroslaw Dziadek
Dec 1, 2017·Frontiers in Molecular Biosciences·Michael A ReicheValerie Mizrahi
Nov 8, 2017·Current Medicinal Chemistry·Lanhua Yi, Xin Lü
Sep 2, 2016·Bioscience Reports·Giulia PergolizziRichard Peter Bowater
Feb 23, 2017·Proceedings of the National Academy of Sciences of the United States of America·Mihaela-Carmen UnciuleacStewart Shuman
Jul 3, 2018·ACS Infectious Diseases·Ramkumar IyerAlice L Erwin
Jun 6, 2014·ACS Medicinal Chemistry Letters·Steven HowardPamela A Williams

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