Design, synthesis, and biological evaluation of crenatoside analogues as novel influenza neuraminidase inhibitors

European Journal of Medicinal Chemistry
Bao-Long ChenGuang-Yao Zeng

Abstract

Natural products, especially derived from TCMH, have been found to exert antiviral effects against influenza virus. Crenatoside, a phenylethanoid glycoside from Pogostemon cablin Benth, which has been shown as a novel effective NA inhibitor previously, is considered as the leading compound for our further SARs studies. This work presented design, synthesis of novel crenatoside analogues from readily available d-Glucose and l-rhamnose in a convergent manner. Furthermore, their biological activities and SARs were also investigated. Especially, compound 2 h showed impressive IC50 = 27.77 μg/mL against NAs, which is 3 folds more potent than the leading compound crenatoside (IC50 = 89.81 μg/mL). These results would promise their therapeutic potential for influenza disease.

References

Apr 2, 2003·Carbohydrate Research·Chuan-Chun ZouXiao-Tian Liang
May 28, 2004·Virus Research·W FiersW Min Jou
Oct 28, 2004·Journal of Virology·Mikhail N MatrosovichHans-Dieter Klenk
Dec 17, 2004·Nature·Jon Clardy, Christopher Walsh
Jul 6, 2005·Chemical & Pharmaceutical Bulletin·Zhongzhen ZhaoZhi-Hong Jiang
Feb 11, 2009·Cell·Rachelle Salomon, Robert G Webster
Mar 5, 2009·The New England Journal of Medicine·Anne Moscona
Feb 10, 2012·Journal of Natural Products·David J Newman, Gordon M Cragg
Sep 10, 2014·Natural Product Reports·Jian Liu, Robert J Linhardt
Dec 22, 2015·European Journal of Medicinal Chemistry·Siwen NiuWenhan Lin

❮ Previous
Next ❯

Citations

Aug 16, 2016·Archivos de bronconeumología·Luciano AmarelleJacob I Sznajder
Jul 12, 2017·Organic & Biomolecular Chemistry·Paulin NkoloValérie Roubaud

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Cardiac Glycosides

Cardiac glycosides are a diverse family of naturally derived compounds that bind to and inhibit na+/k+-atpase. Discover the latest research on cardiac glycosides heres.

Related Papers

Medizinische Monatsschrift für Pharmazeuten
Bioorganic & Medicinal Chemistry Letters
Yuanchao XieWenfang Xu
BMJ : British Medical Journal
Harlan M Krumholz
The New England Journal of Medicine
Anne Moscona
© 2022 Meta ULC. All rights reserved