Design, synthesis and biological mechanisms research on 1,2,3-triazole derivatives of Jiyuan Oridonin A

Bioorganic & Medicinal Chemistry
Yu KeHong-Min Liu

Abstract

Two series of derivatives with 1,2,3-triazole as heterocyclic moiety of Jiyuan Oridonin A, a new ent-kaurene diterpenoid which was isolated from genus Isodon rubescens, were synthesized and biologically evaluated. All the derivatives possessed good anti-proliferative activities. Among them, compound 8g was found to significantly induce cell apoptosis and cell cycle arrest in MGC-803 via a series of signals activated by the increased intracellular ROS levels.

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Citations

Jan 19, 2019·Anti-cancer Agents in Medicinal Chemistry·Wei HouHongtao Xu
Dec 9, 2020·Bioorganic & Medicinal Chemistry·Teerapich KasemsukRungnapha Saeeng
Jan 1, 2021·Bioorganic Chemistry·Xin-Hui ZhangHong-Min Liu
Jul 3, 2020·Journal of Medicinal Chemistry·Hong YaoJinyi Xu
Dec 7, 2021·Frontiers in Chemistry·Xiang ZhangHongtao Xu

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